Denali Therapeutics Inc.
DNLI
Health Care
2
exclusion reasons
1 theme
This page is part of our public exclusion list — a transparency tool that shows which companies we screen out and why. It is not investment advice, and it is not an accusation. But it is subject to change as our understanding of the facts evolves.
Denali Therapeutics is a clinical-stage biotechnology company developing therapeutics for neurodegenerative diseases. Its drug development pipeline relies on animal testing to validate drug candidates, assess safety and efficacy, and meet regulatory requirements for Investigational New Applications (INDs) and clinical trials. The company’s strategy explicitly includes validating biomarkers in animal models prior to human trials. As a pharmaceutical research entity, Denali’s core operations inherently involve the commercial use of animals in laboratory testing.
Denali Therapeutics is a biotechnology company developing central nervous system-targeted enzyme replacement therapies for neurodegenerative diseases. As a pharmaceutical developer, its preclinical research pipeline requires animal testing for regulatory compliance and safety assessment. The company’s published research explicitly references using animal models, including nonrodent species such as rabbits, for general toxicology studies. A 2024 publication lists Denali Therapeutics Inc. as the affiliation for authors conducting this animal testing. Further, the company’s SEC filings acknowledge that “long-term preclinical testing, such as animal tests” is part of the drug development process, and external research on its investigational compounds notes that the studies were funded by Denali. There is no public commitment to alternative testing methods or a phase-out plan for animal use in its research.
Research Sources
1 organization
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