Animal Testing
Conduct Screen Animal Welfare
Companies that test on animals as part of product development, regulatory compliance, or research — pharmaceuticals, cosmetics, chemicals, consumer products, and CROs (contract research organizations). Includes companies that fund, commission, or require animal testing even if outsourced. Distinct from animal_exploitation (commercial use of animals as products) and factory_farming (confinement agriculture).
678 companies currently excluded under this screen
Excluded Companies (678 total)
Showing 678 of 678 companies excluded under this screen.
| Ticker | Company | Reason |
|---|---|---|
| A | Agilent Technologies, Inc. | Agilent is a primary provider of specialized laboratory instruments (LC/MS, microarrays, and "Lab-on-a-Chip" technology) explicitly marketed and used for animal-based drug metabolism, toxicology studi... |
| AAPG | ASCENTAGE PHARMA GROUP INTERNATIONAL | Ascentage Pharma Group International is a clinical-stage biotechnology company developing cancer therapies. Its drug discovery and development pipeline relies on animal testing to evaluate the safety ... |
| ABCL | ABCELLERA BIOLOGICS INC | AbCellera Biologics is a biotechnology company whose core business model relies on the commercial exploitation of animals. The company's primary revenue is derived from discovering and developing ther... |
| ABEO | Abeona Therapeutics Inc. | Abeona Therapeutics is a clinical-stage biopharmaceutical company developing gene and cell therapies for rare diseases. Its lead product candidates, including prademagene zamikeracel (pz-cel) for rece... |
| ABOS | ACUMEN PHARMACEUTICALS INC | Acumen Pharmaceuticals is a clinical-stage biotechnology company whose drug development pipeline relies on animal testing for preclinical research and regulatory compliance. The company’s lead therape... |
| ABSI | ABSCI CORP | Absci is a clinical-stage biotech developing antibody therapeutics (ABS-101 for IBD, ABS-201 for alopecia, ABS-301/501 for oncology). Preclinical drug development inherently involves animal studies. A... |
| ABT | Abbott Laboratories | Abbott Laboratories is a global healthcare company whose pharmaceutical and medical device development requires animal testing for regulatory compliance and product safety validation. The company has ... |
| ABUS | Arbutus Biopharma Corporation | Arbutus Biopharma Corporation is a clinical-stage biopharmaceutical company focused on developing treatments for infectious diseases. Its research and development pipeline for these therapies relies o... |
| ABVX | ABIVAX SA | ABIVAX SA is a clinical-stage biotechnology company whose drug development pipeline relies on animal testing as a core component of its preclinical research and regulatory submission process. The comp... |
| ACAD | ACADIA Pharmaceuticals Inc. | ACADIA Pharmaceuticals Inc. is a biopharmaceutical company focused on the development and commercialization of medicines for central nervous system disorders. Its marketed product, NUPLAZID® (pimavans... |
| ACET | Adicet Bio, Inc. | Adicet Bio, Inc. is a preclinical-stage biotechnology company whose core research and development activities involve animal testing. The company's lease agreements explicitly reference compliance with... |
| ACHV | Achieve Life Sciences, Inc. | Achieve Life Sciences, Inc. is a clinical-stage pharmaceutical company whose lead investigational drug, cytisinicline, is being developed as a smoking cessation treatment. The company's preclinical an... |
| ACIU | AC Immune SA | AC Immune SA is a clinical-stage biopharmaceutical company whose core business model involves animal testing as an integral part of its drug development process. The company is listed by Cruelty Free ... |
| ACLX | ARCELLX INC | Arcellx Inc. is a clinical-stage biotechnology company developing cell therapies for cancer treatment. As documented by Cruelty Free Investors, the company undertakes preclinical studies on animals to... |
| ACRS | Aclaris Therapeutics, Inc. | Aclaris Therapeutics, Inc. is a clinical-stage biotechnology company whose drug development pipeline relies on animal testing. The company’s research into compounds like zunsemetinib (ATI-450) for inf... |
| ADAG | ADAGENE INC | Adagene develops antibody-based oncology therapeutics using its proprietary SAFEbody platform. Its drug candidates require preclinical animal testing as part of FDA-mandated development programs. |
| ADAP | Adaptimmune Therapeutics plc | Adaptimmune Therapeutics plc is a clinical-stage biopharmaceutical company developing engineered T-cell therapies for cancer. Its core pipeline of SPEAR T‑cell candidates targets solid tumors, includi... |
| ADCT | ADC Therapeutics SA | ADC Therapeutics SA is a clinical-stage biotechnology company whose sole commercial product, ZYNLONTA (loncastuximab tesirine-lpyl), is an antibody-drug conjugate for treating relapsed or refractory l... |
| ADIL | Adial Pharmaceuticals, Inc | Adial Pharmaceuticals is a clinical-stage biopharmaceutical company developing AD04 (ondansetron), a selective serotonin-3 receptor antagonist, for the treatment of Alcohol Use Disorder. The company’s... |
| ADPT | Adaptive Biotechnologies Corp | Adaptive Biotechnologies Corp. develops and commercializes immunosequencing technologies used to decode the adaptive immune system for clinical diagnostics and therapeutic discovery. A core component ... |
| AEMD | Aethlon Medical, Inc. | Aethlon Medical, Inc. develops medical devices and therapies targeting cancer and infectious diseases, a process that involves animal testing. The company is explicitly listed by Cruelty Free Investor... |
| AEON | AEON BIOPHARMA INC | AEON Biopharma, Inc. is a clinical-stage biopharmaceutical company whose primary product candidate, ABP-450 (prabotulinumtoxinA), is a botulinum toxin complex. The development of such injectable neuro... |
| AGEN | Agenus Inc. | Agenus Inc. is a biotechnology company whose core business of developing cancer immunotherapies relies on animal testing. The company's pipeline of antibody-based therapies, including its lead candida... |
| AGIO | Agios Pharmaceuticals, Inc. | Agios Pharmaceuticals is a biopharmaceutical company whose core business of developing and marketing novel therapeutics inherently requires animal testing for regulatory compliance and product develop... |
| AGRX | Agile Therapeutics, Inc. | Agile Therapeutics, Inc. is a women's healthcare company that develops and markets prescription contraceptive products. The company's primary product, Twirla® (levonorgestrel and ethinyl estradiol tra... |
| AIM | AIM Immunotech | AIM ImmunoTech is a clinical-stage immuno-pharma company whose research and development pipeline is centered on its lead drug candidate, Ampligen (rintatolimod). The development of pharmaceutical prod... |
| AKBA | Akebia Therapeutics, Inc. | Akebia Therapeutics is a biopharmaceutical company whose drug development pipeline requires animal testing as a standard component of preclinical research and regulatory submissions. The company's lea... |
| AKRO | Akero Therapeutics Inc | Akero Therapeutics is a clinical-stage biotechnology company developing efruxifermin for metabolic dysfunction-associated steatohepatitis (MASH). The company's core research and development activities... |
| AKTX | Akari Therapeutics Plc | Akari Therapeutics is a biopharmaceutical company whose core business involves animal testing as part of its drug development process. The company’s lead clinical-stage programs, including those for c... |
| AKYA | AKOYA BIOSCIENCES INC | Akoya Biosciences Inc. develops and commercializes spatial biology platforms and assays, including its CODEX and PhenoImager systems, which are used for highly multiplexed protein and nucleic acid ima... |
| ALC | Alcon | Alcon, a global medical device and pharmaceutical company specializing in eye care, conducts animal testing as part of its product development and regulatory compliance for ophthalmic devices and medi... |
| ALDX | Aldeyra Therapeutics, Inc. | Aldeyra Therapeutics, Inc. is a biotechnology company focused on developing treatments for immune-mediated and inflammatory diseases. As a pharmaceutical research and development firm, its preclinical... |
| ALEC | Alector Inc | Alector Inc. is a late-stage clinical biotechnology company developing immunotherapies for neurodegenerative diseases, including Alzheimer's disease. The company's drug discovery and development pipel... |
| ALGS | ALIGOS THERAPEUTICS INC | Aligos Therapeutics Inc. is a clinical-stage biopharmaceutical company whose core business model involves the discovery and development of novel therapeutics. The development pathway for these drug ca... |
| ALKS | Alkermes plc | Alkermes plc is a global biopharmaceutical company whose core business model involves the development of medicines that require animal testing for regulatory approval and safety assessment. As a devel... |
| ALLK | Allakos Inc. | Allakos Inc. is a clinical-stage biotechnology company developing therapeutic antibodies for allergic, inflammatory, and fibrotic diseases. Its core research and development activities involve preclin... |
| ALLO | Allogene Therapeutics, Inc. | Allogene Therapeutics is a clinical-stage biotechnology company developing allogeneic CAR T cell therapies for cancer treatment. This research and development process inherently involves animal testin... |
| ALMS | ALUMIS INC | Alumis Inc. is a biotechnology company developing precision immunology therapies. As a biopharmaceutical firm engaged in drug discovery and development, its research and development pipeline inherentl... |
| ALNY | Alnylam Pharmaceuticals, Inc. | Alnylam Pharmaceuticals is a leading developer of RNA interference therapeutics targeting genetically defined diseases across liver, CNS, adipose, and muscle tissues. The company has five approved RNA... |
| ALPMY | ASTELLAS PHARMA NPV | Astellas Pharma conducts animal testing per its Policy on Animal Care and Use. All facilities are AAALAC International accredited. Corporate IACUC oversees testing under 4R Principles. Develops therap... |
| ALT | Altimmune, Inc. | Altimmune is a clinical-stage biopharmaceutical company focused on metabolic and liver diseases. Its lead candidate pemvidutide, a dual GLP-1/glucagon receptor agonist, achieved FDA Breakthrough Thera... |
| ALVO | ALVOTECH | Alvotech develops biosimilar medicines, including equivalents to Humira (adalimumab) and Entyvio (vedolizumab). FDA and EMA regulatory pathways for biosimilars require comparative preclinical pharmaco... |
| ALXO | ALX Oncology Holdings Inc | ALX Oncology develops immuno-oncology therapies targeting CD47, a 'don't eat me' signal exploited by cancer cells. Its lead candidate evorpacept blocks CD47 with high affinity and is being evaluated i... |
| AMGN | Amgen Inc. | Amgen conducts animal testing across its pharmaceutical R&D pipeline, including preclinical studies for biologics, oncology, and cardiovascular therapies. While the company publishes a 3Rs (Replacemen... |
| AMLX | AMYLYX PHARMACEUTICALS INC | Amylyx Pharmaceuticals developed AMX0035 (Relyvrio) for amyotrophic lateral sclerosis using transgenic SOD1G93A mouse models and Sprague Dawley rat neuronal assays. Embryofetal development studies in ... |
| AMPH | Amphastar Pharmaceuticals, Inc. | Amphastar manufactures injectable and inhalation pharmaceuticals including Cortrosyn and morphine sulfate. Pharmaceutical development and biosimilar programs require preclinical animal testing per FDA... |
| AMRN | Amarin Corporation plc | Amarin develops prescription omega-3 therapeutics (Vascepa) for cardiovascular disease. As a pharmaceutical company, Amarin conducts preclinical animal testing as part of its drug development and FDA ... |
| ANAB | AnaptysBio, Inc. | AnaptysBio develops antibody-based therapeutics for inflammatory and autoimmune diseases. Its lead candidate rosnilimab is a novel PD-1 depleter and agonist that targets pathogenic T cells, achieving ... |
| ANGO | AngioDynamics, Inc. | AngioDynamics develops minimally invasive medical devices for vascular access, peripheral vascular disease, and oncology. Its NanoKnife system, named to TIME's 2025 Best Inventions list, uses irrevers... |
| ANIP | ANI PHARMACEUTICALS INC | ANI Pharmaceuticals is a specialty pharmaceutical company that develops and manufactures generic and branded drugs requiring FDA approval. Pharmaceutical development and regulatory submission inherent... |
| ANL | ADLAI NORTYE LTD | Adlai Nortye is a clinical-stage oncology company developing small-molecule therapeutics targeting RAS-driven cancers. Its lead candidate AN9025 is an oral pan-RAS(ON) inhibitor that dosed its first p... |
| ANNX | ANNEXON INC | Annexon Biosciences develops first-in-kind therapeutics targeting C1q, the initiating molecule of the classical complement pathway and a key driver of neurodegeneration. Its lead candidate ANX007 is a... |
| ANRO | ALTO NEUROSCIENCE INC | Alto Neuroscience is a clinical-stage biopharmaceutical company developing precision psychiatry therapeutics that use EEG brain biomarkers to match patients with treatments most likely to help them. I... |
| AORT | Artivion | Artivion (formerly CryoLife) develops aortic repair devices and surgical sealants including the ARCEVO platform. Medical device development requires preclinical animal testing to satisfy FDA safety re... |
| APGE | APOGEE THERAPEUTICS INC | Apogee Therapeutics is a clinical-stage biotechnology company developing antibody therapeutics for immunology and inflammation. Drug development programs require FDA-mandated preclinical animal studie... |
| APLS | Apellis Pharmaceuticals, Inc. | Apellis Pharmaceuticals develops targeted C3 complement therapies across ophthalmology, hematology, and nephrology. The company has two approved medicines: SYFOVRE (pegcetacoplan intravitreal) for geo... |
| AQST | Aquestive Therapeutics, Inc. | Aquestive Therapeutics develops oral film-based drug delivery products using its proprietary PharmFilm technology. Its lead product Anaphylm (dibutepinephrine sublingual film) is an epinephrine prodru... |
| ARDX | Ardelyx, Inc. | Ardelyx, Inc. is a biopharmaceutical company whose product development pipeline requires animal testing to meet regulatory requirements for drug safety and efficacy. As a standard practice in the phar... |
| ARGX | argenx SE | Argenx develops antibody-based therapies targeting FcRn and complement pathways for autoimmune diseases. Its drug pipeline requires preclinical animal testing per FDA regulations; the company publishe... |
| ARMP | ARMATA PHARMACEUTICALS INC | Armata Pharmaceuticals develops bacteriophage-based therapies for antibiotic-resistant infections. Preclinical drug development requires animal testing for regulatory approval. Excluded under animal t... |
| ARQT | Arcutis Biotherapeutics Inc | Arcutis Biotherapeutics develops dermatology therapeutics spanning topical and systemic modalities. Its marketed products include ZORYVE (roflumilast) cream and foam for plaque psoriasis and atopic de... |
| ARVN | Arvinas, Inc. | Arvinas develops targeted protein degradation therapies using proprietary PROTAC technology. Preclinical validation of lead candidates bavdegalutamide (ARV-110, prostate cancer) and vepdegestrant (ARV... |
| ARWR | Arrowhead Pharmaceuticals, Inc. | Arrowhead Pharmaceuticals develops RNA interference (RNAi) therapeutics, a class of drugs that requires extensive preclinical safety and efficacy testing. As a biotechnology company advancing novel dr... |
| ASMB | Assembly Biosciences, Inc. | Assembly Biosciences, Inc. is a biotechnology company whose research and development activities are reported to involve animal testing. This exclusion is based on a flag from Cruelty Free Investors, w... |
| ASND | Ascendis Pharma A/S | Ascendis Pharma develops long-acting endocrine therapies using its TransCon platform, including TransCon hGH (Skytrofa) for growth hormone deficiency and TransCon PTH for hypoparathyroidism. Its drug ... |
| ATAI | ATAI LIFE SCIENCES NV | ATAI Life Sciences develops psychedelic and psychoactive compound-based therapies for mental health disorders. Its drug candidates require preclinical animal testing under FDA regulatory requirements. |
| ATEC | Alphatec Holdings, Inc. | Alphatec Holdings designs, develops, and commercializes technologies for the surgical treatment of spinal disorders, generating approximately $890 million in projected 2026 revenue. Its core portfolio... |
| ATR | APTARGROUP INC | Manufactures and engineers proprietary drug delivery systems (e.g., pMDI valves, nasal pumps) that are actively and mandatorily utilized in pharmaceutical animal studies and in vivo pharmacological te... |
| ATRC | AtriCure, Inc. | AtriCure develops surgical ablation and left atrial appendage management devices for treating atrial fibrillation, backed by over 20 years of innovation and 30,000-plus patients treated with its Isola... |
| AUPH | Aurinia Pharmaceuticals Inc | Aurinia Pharmaceuticals secured FDA approval for voclosporin (Lupkynis) for lupus nephritis based on extensive non-clinical animal testing involving mice, rats, rabbits, minipigs, and non-human primat... |
| AURA | AURA BIOSCIENCES INC | Aura Biosciences develops virus-like drug conjugates for ocular oncology. Preclinical and clinical drug development requires animal models for safety and efficacy testing. Excluded under animal testin... |
| AUTL | Autolus Therapeutics plc | Autolus Therapeutics develops programmed T-cell therapies for cancer and autoimmune diseases. Its lead product AUCATZYL (obecabtagene autoleucel, obe-cel) received FDA approval in 2024 for adult relap... |
| AVBP | ARRIVENT BIOPHARMA INC | ArriVent BioPharma develops precision oncology therapeutics targeting EGFR mutations in non-small cell lung cancer. Its lead candidate firmonertinib is an oral, brain-penetrant, mutation-selective EGF... |
| AVIR | Aviragen Therapeutics, Inc. | Aviragen Therapeutics, Inc. is excluded under the Animal Exploitation category. This exclusion is based on a flag from Cruelty Free Investors, which identifies companies involved in the commercial exp... |
| AVNS | Avanos Medical, Inc. | Avanos develops medical devices for pain management and digestive health, including COOLIEF cooled radiofrequency systems. Its device development programs involve preclinical animal testing per FDA re... |
| AVTX | AVALO THERAPEUTICS INC | Avalo Therapeutics (formerly Cerecor) develops therapeutics for rare and immune diseases, with prior DoD-funded animal model studies. Its drug programs require preclinical animal testing per FDA regul... |
| AVXL | Anavex Life Sciences Corp. | Anavex Life Sciences Corp. is a clinical-stage biopharmaceutical company whose drug development pipeline necessitates animal testing for regulatory compliance. The company’s lead drug candidate, ANAVE... |
| AXSM | Axsome Therapeutics, Inc. | Axsome Therapeutics is a clinical-stage biopharmaceutical company whose product development pipeline relies on animal testing as a standard component of regulatory compliance. The company’s public fil... |
| AYTU | Aytu Biopharma, Inc. | Aytu BioPharma, Inc. is a pharmaceutical company whose product portfolio includes Adzenys XR-ODT, a Schedule II controlled substance amphetamine product indicated for ADHD. The U.S. Food and Drug Admi... |
| AZN | Astrazeneca PLC | AstraZeneca PLC conducts animal testing as part of its pharmaceutical research and development. The company states that animal welfare is a priority, but its operations have been linked to facilities ... |
| BAX | Baxter International Inc. | Baxter International is a global medical products company that develops, manufactures, and markets pharmaceuticals, medical devices, and biotechnology products. A significant portion of its product po... |
| BAYN | BAYER AG | Bayer AG conducts animal testing across its pharmaceutical and crop science divisions, using 44,750 animals in 2024 according to its own disclosures. Approximately 77.7% are mice and rats, with fish (... |
| BBIO | BridgeBio Pharma Inc | BridgeBio Pharma Inc. is a biopharmaceutical company whose core business model involves the discovery and development of transformative medicines. This process inherently requires extensive animal tes... |
| BBNX | BETA BIONICS INC | Beta Bionics develops and manufactures automated insulin delivery systems, including the iLet Bionic Pancreas, which is designed to manage diabetes. The company's core product development and regulato... |
| BBOT | BRIDGEBIO ONCOLOGY THERAPEUTICS INC | BridgeBio Oncology Therapeutics is a clinical-stage company advancing next-generation small molecule therapeutics targeting RAS and PI3K pathway-driven cancers, launched with $200 million in private c... |
| BBWI | BATH & BODY WORKS INC | Bath & Body Works manufactures and sells personal care and home fragrance products, a category where animal testing for safety is a common industry practice. The company states it does not conduct ani... |
| BCAB | BIOATLA INC | BioAtla Inc. is a clinical-stage biotechnology company whose core business model involves the development of monoclonal antibody therapies. This process inherently requires extensive animal testing to... |
| BCAX | BICARA THERAPEUTICS INC | Bicara Therapeutics Inc. is a clinical-stage biotechnology company developing bifunctional antibody therapies for cancer treatment. As part of its pharmaceutical product development and regulatory com... |
| BCDA | BIOCARDIA INC | BioCardia, Inc. is a clinical-stage regenerative medicine company developing cell and cell-based therapeutics for cardiovascular diseases. Its product candidates, including CardiALLO allogeneic cell t... |
| BCLI | Brainstorm Cell Therapeutics Inc. | Excluded under ECIC's animal testing policy. This company conducts or commissions preclinical animal testing as part of its product development program. For pharmaceutical and biotechnology companies,... |
| BCPC | Balchem Corporation | Balchem Corporation operates an Animal Nutrition & Health segment that develops and sells nutritional ingredients and solutions for animal feed. This business supplies additives designed to enhance th... |
| BCRX | BioCryst Pharmaceuticals, Inc. | BioCryst Pharmaceuticals conducts animal testing as a core component of its drug development and regulatory approval process. The company’s research pipeline, including therapies for hereditary angioe... |
| BCYC | Bicycle Therapeutics PLC | Bicycle Therapeutics develops Bicycle toxin conjugates (BTCs) for oncology using constrained bicyclic peptides. Its novel drug modality requires preclinical animal testing under FDA regulatory require... |
| BDRX | BIODEXA PHARMACEUTICALS PLC | Biodexa Pharmaceuticals plc conducts pre-clinical studies of its drug candidates on animals as part of its research and development process. This is a standard, material phase of pharmaceutical develo... |
| BDTX | BLACK DIAMOND THERAPEUTICS INC | Black Diamond Therapeutics is a clinical-stage biotechnology company developing small molecule kinase inhibitors for cancer treatment. As part of its drug discovery and development pipeline, the compa... |
| BDX | Becton, Dickinson and Company | Becton, Dickinson and Company (BD) is a global medical technology company whose product development and regulatory compliance activities necessitate animal testing. The company manufactures medical de... |
| BEAM | Beam Therapeutics Inc | Beam Therapeutics is a biotechnology company whose core business model involves the commercial exploitation of animals for research and development. The company’s precision gene editing platform and p... |
| BHC | Bausch Health Companies Inc. | Bausch Health Companies Inc. develops, manufactures, and markets a portfolio of pharmaceutical, medical device, and over-the-counter health products. As a global pharmaceutical company, its core busin... |
| BHVN | Biohaven Pharmaceutical Holding Company Ltd. | Biohaven Pharmaceutical Holding Company Ltd. is a biopharmaceutical company whose core business model involves the development of novel therapeutics for neurological and neuropsychiatric disorders. A ... |
| BIIB | Biogen Inc. | Biogen Inc. develops and markets therapies for neurological diseases, a process that inherently requires animal testing for regulatory approval and safety validation. The company’s portfolio, includin... |
| BIO | Bio-Rad Laboratories, Inc. | Bio-Rad Laboratories develops, manufactures, and sells a wide range of instruments, test kits, and reagents used in biomedical research and clinical diagnostics. A core segment of its product portfoli... |
| BIOA | BIOAGE LABS INC | BioAge Labs conducts preclinical research using animal models to develop therapeutics targeting aging-related diseases. The company’s core business model relies on animal testing as a standard compone... |
| BIVI | BIOVIE INC | BioVie Inc. is a clinical-stage biopharmaceutical company whose primary business activity is developing and testing new drug candidates. Its leading product candidate, NE3107, has progressed through c... |
| BLCO | Bausch & lomb | Bausch & Lomb requires animal testing as part of its product development and regulatory compliance for its contact lenses, lens care solutions, and ophthalmic pharmaceuticals. The company’s supplier c... |
| BLTE | BELITE BIO INC | Belite Bio develops therapeutics for retinal diseases including geographic atrophy and Stargardt disease. Its ophthalmic drug pipeline requires preclinical animal testing under FDA regulatory requirem... |
| BLUE | bluebird bio, Inc. | bluebird bio is a biotechnology company that develops gene therapies for severe genetic diseases. This research and development process involves animal testing as a standard component of preclinical s... |
| BMEA | BIOMEA FUSION INC | Biomea Fusion Inc. is a preclinical-stage biotechnology company whose research and development pipeline relies on animal testing. The company's primary drug candidates are investigated using in vivo m... |
| BMRA | Biomerica, Inc. | Biomerica, Inc. develops, manufactures, and markets medical diagnostic test kits, primarily using enzyme-linked immunosorbent assay (ELISA) technology. A core component of ELISA development and produc... |
| BMRN | BioMarin Pharmaceutical Inc. | BioMarin Pharmaceutical Inc. conducts animal testing as a core part of its pre-clinical drug development process. The company develops and commercializes therapies for rare genetic diseases, a process... |
| BNTC | Benitec Biopharma Limited | Benitec Biopharma is a clinical-stage biotechnology company developing gene therapies for human diseases, a process that inherently requires animal testing for preclinical safety and efficacy data. Th... |
| BNTX | BioNTech SE | BioNTech develops mRNA-based vaccines and immunotherapies, including its COVID-19 vaccine with Pfizer and cancer vaccine candidates. Its mRNA pipeline requires preclinical animal testing per FDA regul... |
| BOLD | Audentes Therapeutics, Inc. | Audentes Therapeutics, Inc. develops and commercializes adeno-associated virus (AAV) gene therapies for severe neuromuscular diseases. The company’s research and development pipeline relies on preclin... |
| BPMC | Blueprint Medicines Corporation | Blueprint Medicines Corporation is a biotechnology company that researches, develops, and commercializes pharmaceutical drugs. The standard development pathway for such therapeutics involves preclinic... |
| BPTH | Bio-Path Holdings, Inc. | Bio-Path Holdings, Inc. is a preclinical-stage biotechnology company whose core business model involves conducting animal testing to develop its drug candidates. The company’s primary assets, includin... |
| BSGM | BioSig Technologies, Inc. | BioSig develops bioelectronic signal processing technology for cardiac electrophysiology procedures. Its medical device development requires preclinical animal testing to meet FDA safety standards. |
| BSX | Boston Scientific Corporation | Boston Scientific Corporation develops, manufactures, and markets medical devices, a product category that requires animal testing for regulatory approval and safety validation under current FDA and i... |
| BTAI | BioXcel Therapeutics, Inc. | BioXcel Therapeutics, Inc. is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing to meet regulatory requirements. The company's SEC filings routinely c... |
| BVS | Bioventus Inc | Bioventus develops orthobiologic products for musculoskeletal healing including bone growth stimulators and hyaluronic acid injections. Its device and biologic development requires preclinical animal ... |
| BYRN | BYRNA TECHNOLOGIES INC | Byrna Technologies Inc. manufactures and sells kinetic impact projectile launchers, commonly known as less-lethal launchers or pepperball guns, designed for use against humans. The company's core prod... |
| BYSI | BeyondSpring, Inc. | BeyondSpring is a clinical-stage biopharmaceutical company developing cancer therapies. Its lead drug candidate, plinabulin, has progressed through clinical trials, a process that typically requires a... |
| CABA | CABALETTA BIO INC | Cabaletta Bio is a clinical-stage biotechnology company developing engineered T cell therapies for autoimmune diseases. Its research and development pipeline relies on animal testing to assess the saf... |
| CADL | CANDEL THERAPEUTICS INC | Candel Therapeutics is a clinical-stage biotechnology company whose core business model involves developing cancer therapies that require animal testing for regulatory approval and research. The compa... |
| CAI | CARIS LIFE SCIENCES INC | Caris Life Sciences develops and markets cancer diagnostic tests, including its Caris Molecular Intelligence platform, which relies on proprietary assays to analyze tumor tissue. The development and v... |
| CALC | CALCIMEDICA INC | CalciMedica is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s lead investigational compound, Auxora™, has been evaluated in preclini... |
| CANF | Can-Fite Biopharma Ltd | Can-Fite Biopharma Ltd. is a clinical-stage pharmaceutical company whose drug development pipeline relies on animal testing to meet regulatory requirements for safety and efficacy. The company's lead ... |
| CAPR | Capricor Therapeutics, Inc. | Capricor Therapeutics is a biotechnology company whose primary product candidates are derived from human cells. However, its development pipeline includes therapies for Duchenne muscular dystrophy (DM... |
| CARL | CARLSMED INC | Carlsmed Inc. is a medical device company whose primary commercial product is a spinal implant system designed for use in spinal fusion surgeries. The company's business model is predicated on the sal... |
| CARM | CARISMA THERAPEUTICS INC | Carisma Therapeutics is a clinical-stage biotechnology company pioneering macrophage engineering to develop therapies for fibrosis and cancer. Its core research and development model relies on preclin... |
| CASI | CASI Pharmaceuticals, Inc. | CASI Pharmaceuticals, Inc. is a biopharmaceutical company whose business model is inherently dependent on animal testing. The company’s own regulatory filings state that preclinical studies involving ... |
| CATX | PERSPECTIVE THERAPEUTICS INC | Perspective Therapeutics develops targeted alpha-particle radiopharmaceuticals for cancer treatment. Its radioligand therapy pipeline requires preclinical animal testing under FDA regulatory requireme... |
| CBIO | Catalyst Biosciences, Inc. | Catalyst Biosciences, Inc. is a clinical-stage biopharmaceutical company whose business model is predicated on animal testing. The company develops and seeks to commercialize novel protease medicines,... |
| CBLL | CERIBELL INC | Ceribell Inc. develops and markets medical devices, including its flagship EEG headband system, which incorporates disposable electrodes. The company’s product development and regulatory testing proce... |
| CCCC | C4 Therapeutics Inc | C4 Therapeutics is a clinical-stage biopharmaceutical company whose business model requires animal testing as a core component of its drug development process. The company’s SEC filings explicitly sta... |
| CDT | CONDUIT PHARMACEUTICALS INC | Conduit Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company whose business model inherently relies on animal testing. The company develops novel therapeutics, a process that requires pr... |
| CDTX | Cidara Therapeutics, Inc. | Cidara Therapeutics, Inc. is a biotechnology company whose core research and development activities rely on animal testing. The company's lead antifungal candidate, rezafungin, was advanced through pr... |
| CDXS | Codexis, Inc. | Codexis engineers enzymes for pharmaceutical manufacturing and gene therapy applications. Its biocatalyst and therapeutic enzyme programs involve preclinical animal testing under FDA regulatory pathwa... |
| CELC | Celcuity Inc. | Celcuity Inc. is a clinical-stage biotechnology company whose drug development pipeline includes oncology therapeutics. The company's preclinical and clinical research activities inherently involve an... |
| CELU | Celularity Inc | Celularity Inc. is a clinical-stage biotechnology company developing cellular and biomaterial-based therapeutics derived from human placental cells. As a pharmaceutical developer, its research pipelin... |
| CERS | Cerus Corporation | Cerus Corporation develops and commercializes the INTERCEPT Blood System, a pathogen reduction technology for blood components. The company’s product development and regulatory compliance processes re... |
| CGEM | CULLINAN ONCOLOGY INC | Cullinan Oncology is a clinical-stage biopharmaceutical company whose core business model involves developing cancer therapies through preclinical and clinical research that requires animal testing. T... |
| CGEN | Compugen Ltd. | Compugen Ltd. is a clinical-stage biopharmaceutical company whose core business involves developing therapeutic antibodies. This drug discovery and development process inherently requires animal testi... |
| CGON | CG ONCOLOGY INC | CG Oncology is a clinical-stage biopharmaceutical company developing cancer therapeutics. As part of its drug development process, the company conducts preclinical animal testing to assess the safety ... |
| CHD | Church & Dwight Company, Inc. | Listed on PETA's "Companies That Do Test on Animals" for consumer brands including Arm & Hammer, Arrid, Aim, OxiClean. Company policy permits animal testing "when required by law" — a loophole exploit... |
| CHRS | Coherus BioSciences, Inc. | Coherus BioSciences is a commercial-stage biopharmaceutical company whose core business is developing and marketing biologic cancer therapies. The development of these drugs requires animal testing fo... |
| CHWY | CHEWY INC | Chewy, Inc. operates as a major online retailer of pet food, supplies, and medications. In December 2023, the U.S. Food and Drug Administration issued a warning letter to Chewy for introducing misbran... |
| CL | Colgate-Palmolive Company | Colgate-Palmolive Company states it declared a voluntary moratorium on animal testing in 1999 and is committed to its elimination. However, its Product Safety Research Policy clarifies that all of its... |
| CLDI | CALIDI BIOTHERAPEUTICS INC | Calidi Biotherapeutics is a clinical-stage biotechnology company whose core therapeutic platform is dependent on animal testing. Its lead product candidates, including CLD-101 for treating solid tumor... |
| CLDX | Celldex Therapeutics, Inc. | Celldex Therapeutics is a clinical-stage biotechnology company developing antibody-based therapeutics for cancer and inflammatory diseases. Its drug candidates require preclinical animal testing as pa... |
| CLGN | CollPlant Holdings, Ltd. | CollPlant Holdings is a regenerative medicine company whose core technology platform is derived from tobacco plants genetically engineered to produce recombinant human collagen. The company’s commerci... |
| CLLS | Cellectis S.A. | Cellectis S.A. is a clinical-stage biotechnology company developing allogeneic CAR-T cell therapies for cancer treatment. The company’s product development pipeline, as detailed in its annual SEC Form... |
| CLNN | CLENE INC | Clene develops clean-surfaced nanotechnology therapeutics for neurodegenerative diseases including ALS and MS. Its drug candidates require preclinical animal testing per FDA regulations. |
| CLPT | CLEARPOINT NEURO INC | ClearPoint Neuro Inc. manufactures and sells stereotactic neurosurgical systems and disposable products designed for use in animal research. The company’s ClearPoint Neuro Navigation System is markete... |
| CLRB | Cellectar Biosciences, Inc. | Cellectar Biosciences, Inc. is a clinical-stage biopharmaceutical company whose core business is the development of targeted radiotherapeutic and chemotherapeutic agents for cancer treatment. As docum... |
| CLSD | Clearside Biomedical, Inc. | Clearside Biomedical develops suprachoroidal injection therapies for retinal diseases. Its novel ocular drug delivery platform requires preclinical animal testing under FDA regulatory requirements. |
| CLYM | CLIMB BIO INC | Climb Bio (formerly Eliem Therapeutics) utilized nonhuman primate models to validate its licensed anti-APRIL monoclonal antibody CLYM116, presenting the primate data in a September 2025 investor webca... |
| CMPS | COMPASS PATHWAYS PLC | Compass Pathways PLC is a biotechnology company developing psilocybin-based treatments for mental health conditions, including treatment-resistant depression. The company’s core research and developme... |
| CMPX | COMPASS THERAPEUTICS INC | Compass Therapeutics is a clinical-stage biopharmaceutical company whose core business model involves the development of proprietary antibody-based therapeutics. This research and development process ... |
| CMRX | Chimerix, Inc. | Chimerix, Inc. is a biopharmaceutical company whose core business of developing antiviral and oncology therapeutics relies on animal testing as a standard component of its preclinical research and reg... |
| CNMD | CONMED Corporation | CONMED Corporation manufactures surgical instruments and medical devices for orthopedic, general, and gynecologic surgery. The company is listed by Cruelty Free Investors for animal testing in its pro... |
| CNTA | Centessa Pharmaceuticals PLC | Centessa Pharmaceuticals PLC is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s lead investigational candidates, including serpinPC f... |
| CNTB | CONNECT BIOPHARMA HOLDINGS LTD | Connect Biopharma Holdings Limited is a clinical-stage biopharmaceutical company whose core research and development activities rely on animal testing. The company’s pipeline of immunology-focused dru... |
| COCH | ENVOY MEDICAL INC | Envoy Medical Inc. develops and seeks to commercialize the Acclaim fully implanted cochlear implant system. The company's regulatory filings with the U.S. Food and Drug Administration explicitly state... |
| COCP | Cocrystal Pharma, Inc. | Cocrystal Pharma develops antiviral therapeutics targeting influenza, COVID-19, and norovirus using structure-based drug design. Its antiviral pipeline requires preclinical animal testing per FDA regu... |
| CODX | Co-Diagnostics, Inc. | Co-Diagnostics develops molecular diagnostic products including PCR-based testing platforms. Diagnostic development and validation involves preclinical animal-derived sample testing per regulatory req... |
| COGT | COGENT BIOSCIENCES INC | Cogent Biosciences is a clinical-stage biotechnology company developing targeted therapies for genetically defined diseases. Its drug discovery and development pipeline relies on preclinical animal te... |
| COLL | Collegium Pharmaceutical, Inc. | Collegium Pharmaceutical, Inc. is a specialty pharmaceutical company focused on developing and commercializing treatments for pain management, including its abuse-deterrent extended-release oxycodone ... |
| CORT | Corcept Therapeutics Incorporated | Corcept Therapeutics is a pharmaceutical company that develops and markets drugs for severe metabolic, oncologic, and psychiatric disorders. Its lead product, Korlym, is a cortisol modulator used to t... |
| COTY | Coty Inc. | Coty Inc. is a global beauty company with a portfolio of prestige and mass-market brands in fragrance, color cosmetics, and skincare. Its products are sold in over 150 countries, including China, wher... |
| CPHI | China Pharma Holdings, Inc. | China Pharma Holdings, Inc. is a pharmaceutical company operating in China, a jurisdiction where animal testing is frequently required by law for drug development and regulatory approval. The company'... |
| CPIX | Cumberland Pharmaceuticals Inc. | Cumberland Pharmaceuticals Inc. is a pharmaceutical company that develops and markets prescription products. The company's business model inherently involves animal testing as part of the drug develop... |
| CPRX | Catalyst Pharmaceuticals, Inc. | Catalyst Pharmaceuticals markets Firdapse (amifampridine) for Lambert-Eaton myasthenic syndrome and develops therapies for rare neurological diseases. Its drug development requires preclinical animal ... |
| CRBP | Corbus Pharmaceuticals Holdings, Inc. | Corbus Pharmaceuticals Holdings, Inc. is a clinical-stage biotechnology company whose business model is predicated on the development of novel drug candidates. As a pharmaceutical research entity, its... |
| CRBU | Caribou Biosciences Inc | Caribou Biosciences conducts preclinical studies of its drug candidates on animals to assess safety and efficacy. The company’s research protocols, as described in its own reports, involve administeri... |
| CRDF | CARDIFF ONCOLOGY INC | Cardiff Oncology develops cancer therapeutics, including its lead candidate onvansertib, which requires animal testing as part of the pre-clinical drug development process mandated by regulatory agenc... |
| CRGX | CARGO THERAPEUTICS INC | CARGO Therapeutics is a clinical-stage biotechnology company developing cell therapies for cancer. Its lead product candidate, CRG-022, is an autologous CD22-directed chimeric antigen receptor (CAR) T... |
| CRIS | Curis, Inc. | Curis, Inc. is a biotechnology company whose core business model involves developing cancer therapeutics. The company's drug development pipeline necessitates extensive animal testing as part of precl... |
| CRL | Charles River Laboratories International, Inc. | Charles River Laboratories International, Inc. is a global contract research organization (CRO) whose core business model involves breeding, selling, and testing on animals for pharmaceutical, biotech... |
| CRMD | CorMedix Inc | CorMedix Inc. is a clinical-stage pharmaceutical company whose lead product candidate, DefenCath, is a catheter lock solution designed to prevent bloodstream infections. The company’s regulatory filin... |
| CRNX | Crinetics Pharmaceuticals, Inc. | Crinetics Pharmaceuticals conducts preclinical testing of its drug candidates on animals, including dogs, as part of its product development process. The company's research protocols have involved ora... |
| CRSP | CRISPR Therapeutics AG | CRISPR Therapeutics develops gene-editing therapies using CRISPR/Cas9, including Casgevy for sickle cell disease and programs for alpha-1 antitrypsin deficiency. Its gene therapy pipeline requires pre... |
| CRVS | Corvus Pharmaceuticals, Inc. | Corvus Pharmaceuticals develops immuno-oncology therapies targeting adenosine pathways in cancer. Its drug pipeline requires preclinical animal testing as mandated by FDA regulations. |
| CSBR | Champions Oncology, Inc. | Champions Oncology, Inc. operates a contract research organization (CRO) whose core business model involves testing oncology drug candidates on animals. The company provides patient-derived xenograft ... |
| CSTL | Castle Biosciences Inc | Castle Biosciences develops genomic diagnostics for dermatologic cancers and other conditions. Diagnostic test validation involves preclinical animal-derived tissue studies per FDA requirements. |
| CTLT | Catalent, Inc. | Catalent, Inc. is a contract development and manufacturing organization (CDMO) that provides drug development, delivery technologies, and biologics manufacturing services to pharmaceutical companies. ... |
| CTMX | CytomX Therapeutics, Inc. | CytomX Therapeutics is a clinical-stage, oncology-focused biopharmaceutical company. Its core business is the discovery and development of novel antibody-based cancer therapies. The preclinical develo... |
| CTNM | CONTINEUM THERAPEUTICS INC | Contineum Therapeutics conducts preclinical research that requires animal testing to assess the safety and efficacy of its pharmaceutical candidates. The company’s public research, such as the identif... |
| CTOR | CITIUS ONCOLOGY INC | Citius Oncology develops oncology therapeutics. Its cancer drug pipeline requires preclinical animal testing as mandated by FDA drug development regulations. |
| CTSO | Cytosorbents Corporation | Cytosorbents Corporation manufactures and markets a medical device called VetResQ, which is a veterinary version of its CytoSorb blood purification technology. The company actively commercializes this... |
| CTXR | Citius Pharmaceuticals, Inc. | Citius Pharmaceuticals, Inc. is a specialty pharmaceutical company that develops critical care products, a sector that inherently relies on animal testing for regulatory compliance and product develop... |
| CUE | Cue Biopharma, Inc. | Cue Biopharma is a clinical-stage biopharmaceutical company developing a novel class of injectable biologic drugs for oncology and immunology. As a standard part of its preclinical development process... |
| CVAC | CureVac NV | CureVac NV is a clinical-stage biotechnology company whose core business model involves developing messenger RNA (mRNA) vaccines and therapeutics. This research and development process is fundamentall... |
| CVM | Cel-Sci Corporation | Cel-Sci Corporation is a biotechnology company whose core research and development activities involve animal testing. The company’s primary clinical-stage asset, Multikine, is an immunotherapy for hea... |
| CYBN | CYBIN INC | Cybin Inc. is a clinical-stage biopharmaceutical company developing psychedelic-based therapeutics for mental health conditions. Its drug development pipeline requires preclinical animal testing to as... |
| CYCC | Cyclacel Pharmaceuticals, Inc. | Cyclacel develops cell cycle-based cancer therapeutics targeting CDK inhibition. Its oncology drug pipeline requires preclinical animal testing under FDA regulatory requirements. |
| CYCN | CYCLERION THERAPEUTICS INC | Cyclerion Therapeutics is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing as a standard, required component of the regulatory process. The company’s... |
| CYTK | Cytokinetics, Incorporated | Cytokinetics, Incorporated is a biopharmaceutical company whose drug development pipeline relies on animal testing. The company develops therapies for cardiovascular and neuromuscular diseases, a proc... |
| DARE | Dare Bioscience, Inc. | Daré Bioscience, Inc. is a clinical-stage biopharmaceutical company focused on women's health. Its product development pipeline for novel intravaginal rings and other drug candidates requires animal t... |
| DAWN | Day One Biopharmaceuticals Inc | Day One Biopharmaceuticals is a clinical-stage oncology company whose core business model requires animal testing for drug development and regulatory approval. As a biopharmaceutical enterprise, its r... |
| DBVT | DBV Technologies S.A. | DBV Technologies S.A. is a clinical-stage biopharmaceutical company whose core product development pipeline relies on animal testing. The company’s lead investigational therapy for food allergies, Via... |
| DCTH | Delcath Systems, Inc. | Delcath Systems, Inc. develops and commercializes HEPZATO KIT (melphalan hydrochloride), a drug-device combination product designed for a procedure called percutaneous hepatic perfusion (PHP). The PHP... |
| DGX | Quest Diagnostics Incorporated | Quest Diagnostics Incorporated is a leading provider of diagnostic information services, operating clinical laboratories that perform medical testing. As part of its service offerings and research act... |
| DMAC | DiaMedica Therapeutics Inc. | DiaMedica Therapeutics is a clinical-stage biopharmaceutical company whose lead drug candidate, DM199, is a recombinant form of human tissue kallikrein 1 (KLK1) being developed for acute ischemic stro... |
| DNLI | Denali Therapeutics Inc. | Denali Therapeutics is a biotechnology company developing central nervous system-targeted enzyme replacement therapies for neurodegenerative diseases. As a pharmaceutical developer, its preclinical re... |
| DNTH | DIANTHUS THERAPEUTICS INC | Dianthus Therapeutics is a clinical-stage biotechnology company developing monoclonal antibody therapeutics. Its lead drug candidate, DNTH103, is being evaluated in clinical trials for autoimmune dise... |
| DRRX | DURECT Corporation | DURECT develops therapeutics for liver diseases using its epigenomic regulator platform. Its drug development programs require preclinical animal testing as mandated by FDA regulations. |
| DRTS | ALPHA TAU MEDICAL LTD | Alpha Tau Medical Ltd. develops and commercializes the Alpha DaRT (Diffusing Alpha-emitters Radiation Therapy) system, a targeted cancer treatment technology. The company’s pre-clinical research and d... |
| DSGN | DESIGN THERAPEUTICS INC | Design Therapeutics is a clinical-stage biotech developing gene-targeted therapies for degenerative diseases. Its preclinical pipeline requires animal models for pharmacology and toxicology studies as... |
| DXCM | DexCom, Inc. | DexCom, Inc. conducts animal testing as part of the regulatory approval process for its medical devices. The company’s De Novo classification request for its Dexcom G6 continuous glucose monitoring sy... |
| DYN | DYNE THERAPEUTICS INC | Dyne Therapeutics is a biotechnology company developing therapeutics for genetically driven muscle diseases. Its lead programs utilize antibody-oligonucleotide conjugates to deliver genetic medicines ... |
| EBS | Emergent Biosolutions, Inc. | Emergent BioSolutions develops and manufactures medical countermeasures for public health threats, including vaccines and therapeutics for anthrax, smallpox, and botulism. Its product development pipe... |
| ECOR | electroCore, Inc. | electroCore, Inc. manufactures and markets gammaCore, a non-invasive vagus nerve stimulator. The device’s development and regulatory approval process relied on animal testing. The company’s own Form S... |
| EDIT | Editas Medicine, Inc. | Editas Medicine, Inc. is a clinical-stage biotechnology company developing CRISPR-based gene-editing therapies. As part of its product development and regulatory compliance process, the company conduc... |
| EGRX | Eagle Pharmaceuticals, Inc. | Eagle Pharmaceuticals, Inc. is a pharmaceutical company whose business model inherently involves animal testing. The company develops and commercializes injectable products, a process that requires ex... |
| EL | Estee Lauder Companies, Inc. (The) | The Estée Lauder Companies Inc. is a global cosmetics manufacturer whose product portfolio, including skincare, makeup, and fragrances, is subject to animal testing requirements in certain internation... |
| ELAN | Elanco Animal Health Incorporated | Elanco Animal Health is a global animal health company that develops, manufactures, and markets products for farm animals and pets. Its core business is the commercial exploitation of animals through ... |
| ELDN | ELEDON PHARMACEUTICALS INC | Eledon Pharmaceuticals is a clinical-stage biotechnology company whose core business model involves conducting animal testing as a required component of its drug development process. The company’s lea... |
| ELTX | ELICIO THERAPEUTICS INC | Elicio Therapeutics is a clinical-stage biotechnology company whose pipeline is built on testing novel cancer immunotherapies in animal models. The company’s lead product candidates, including its lym... |
| ELVN | ENLIVEN THERAPEUTICS INC | Enliven Therapeutics is a clinical-stage biopharmaceutical company developing small molecule kinase inhibitors for oncology. Drug development programs require FDA-mandated preclinical animal studies f... |
| EMBC | EMBECTA CORP | Embecta (spun off from BD) manufactures diabetes care devices including insulin delivery systems. Its medical device development requires preclinical animal testing to meet FDA safety standards. |
| ENGN | ENGENE HOLDINGS INC | enGene Holdings develops non-viral gene therapy treatments for bladder cancer using its proprietary DDX delivery platform. Its lead candidate detalimogene voraplasmid achieved a 62% complete response ... |
| ENSC | ENSYSCE BIOSCIENCES INC | Ensysce Biosciences is a clinical-stage pharmaceutical company developing novel opioid painkillers. The development of these drugs requires extensive animal testing to meet regulatory requirements for... |
| ENTA | Enanta Pharmaceuticals, Inc. | Enanta Pharmaceuticals is a biotechnology company whose core business model involves animal testing as a standard component of drug development. The company's preclinical research activities, as discl... |
| ENTX | Entera Bio Ltd. | Entera Bio Ltd. is a clinical-stage biotechnology company developing oral peptide therapeutics. Its drug development pipeline relies on animal testing as a required component of preclinical research a... |
| EOLS | Evolus, Inc. | Evolus, Inc. develops and markets aesthetic neurotoxin products, primarily Jeuveau® for cosmetic wrinkle treatment. The company's regulatory filings and product development process explicitly require ... |
| EPC | Edgewell Personal Care Co | Edgewell Personal Care Co manufactures and markets consumer products, including Playtex tampons, Hawaiian Tropic sun care, and Wet Ones hand wipes. The company’s business model relies on animal testin... |
| EPIX | ESSA Pharma Inc. | ESSA Pharma Inc. is a clinical-stage pharmaceutical company whose drug development pipeline relies on preclinical animal testing. The company's lead therapeutic candidates for treating prostate cancer... |
| EQ | Equillium, Inc. | Equillium develops biotechnology therapeutics targeting the CD6-ALCAM pathway for severe autoimmune and inflammatory diseases. Its drug candidates require preclinical animal testing per FDA regulation... |
| ERAS | Erasca Inc | Erasca Inc. is a clinical-stage precision oncology company developing drugs to treat cancers driven by the RAS/MAPK pathway. The preclinical and clinical development of these pharmaceutical candidates... |
| ERNA | ERNEXA THERAPEUTICS INC | Ernexa Therapeutics is a preclinical-stage biotechnology company developing synthetic allogeneic iMSC (induced mesenchymal stem cell) therapies for cancer and autoimmune diseases. As a standard practi... |
| ESLA | ESTRELLA IMMUNOPHARMA INC | Estrella Immunopharma Inc. is a clinical-stage biotechnology company whose core business model relies on animal testing to develop its therapeutic candidates. The company’s preclinical research and re... |
| ESPR | Esperion Therapeutics, Inc. | Esperion Therapeutics, Inc. is a pharmaceutical company whose drug development pipeline relies on animal testing. The company’s primary investigational and approved products, which are small-molecule ... |
| ETON | Eton Pharmaceutcials, Inc. | Eton Pharmaceuticals develops and commercializes pharmaceutical products, a business activity that inherently involves animal testing for regulatory compliance and product safety. The company’s pipeli... |
| EVO | EVOTEC SE | Evotec SE operates a global drug discovery and development business that relies on animal testing as a core component of its preclinical research services. The company's operations include multiple si... |
| EVOK | Evoke Pharma, Inc. | Evoke Pharma, Inc. is a pharmaceutical company whose core business involves animal testing. The company's drug development pipeline necessitates preclinical testing on animals as a standard regulatory... |
| EWTX | Edgewise Therapeutics Inc | Edgewise Therapeutics develops muscle-targeting therapeutics for muscular dystrophies and cardiac conditions. Its lead candidate sevasemten is a first-in-class oral fast skeletal myosin inhibitor desi... |
| EXAI | EXSCIENTIA PLC | Exscientia PLC is an artificial intelligence-driven biotechnology company whose core business model involves the discovery and development of pharmaceutical drugs using AI. A central component of this... |
| EXEL | Exelixis, Inc. | Exelixis is a commercial-stage oncology company with approximately $2.4 billion in projected 2026 revenue. Its approved drug cabozantinib (CABOMETYX) treats renal cell carcinoma and hepatocellular car... |
| EYPT | EyePoint Pharmaceuticals, Inc. | EyePoint Pharmaceuticals develops sustained-release ophthalmic drug delivery systems. As an FDA-regulated pharmaceutical company, its product development requires animal studies for preclinical safety... |
| FATE | Fate Therapeutics, Inc. | Fate Therapeutics is a clinical-stage biotechnology company developing induced pluripotent stem cell (iPSC)-derived cell therapies for cancer and autoimmune disorders. The company's drug development p... |
| FBIO | Fortress Biotech, Inc. | Fortress Biotech is a biopharmaceutical company dedicated to acquiring, developing, and commercializing pharmaceutical and biotechnology products. The company’s business model inherently requires anim... |
| FBLG | FIBROBIOLOGICS INC | FibroBiologics, Inc. is a clinical-stage biotechnology company whose core business is the development of therapeutic products derived from fibroblasts, a type of cell. A central component of its resea... |
| FBRX | FORTE BIOSCIENCES INC | Forte Biosciences is a clinical-stage biotechnology company developing therapeutic candidates for autoimmune and inflammatory diseases. Its primary drug candidate, FB-401, is a topical live biotherape... |
| FDMT | 4D Molecular Therapeutics Inc | 4D Molecular Therapeutics is a biotechnology company whose core business model involves the development of gene therapy products. This process requires extensive animal testing to meet regulatory requ... |
| FENC | Fennec Pharmaceuticals Inc. | Fennec Pharmaceuticals Inc. is a biopharmaceutical company focused on the development of PEDMARK (sodium thiosulfate), an FDA-approved drug to reduce the risk of ototoxicity associated with cisplatin ... |
| FGEN | FibroGen, Inc | FibroGen, Inc. is a biopharmaceutical company focused on discovering, developing, and commercializing novel therapeutics for fibrosis, anemia, and cancer. As a clinical-stage biotech, its product deve... |
| FHTX | FOGHORN THERAPEUTICS INC | Foghorn Therapeutics is a preclinical-stage biotechnology company whose research and development pipeline is built on animal testing. The company’s core platform and drug discovery programs rely on in... |
| FMS | Fresenius Medical Care Corporation | Fresenius Medical Care Corporation is a global healthcare company whose core business includes the development and manufacturing of medical devices, pharmaceuticals, and dialysis products. As document... |
| FOLD | Amicus Therapeutics, Inc. | Amicus Therapeutics is a biotechnology company whose core business model relies on animal testing to develop and gain regulatory approval for its drug candidates. The company’s lead investigational th... |
| FRPT | Freshpet, Inc. | Freshpet manufactures and markets refrigerated pet food products derived from animal ingredients. The company's business model is built on processing animal-derived materials into pet food, which cons... |
| FTRE | FORTREA HOLDINGS INC | Fortrea Holdings Inc. operates a contract research organization that conducts animal testing for pharmaceutical and biotechnology clients. The company’s business model is built on providing preclinica... |
| FULC | Fulcrum Therapeutics Inc | Fulcrum Therapeutics is a clinical-stage biopharmaceutical company developing treatments for genetically defined diseases including FSHD. Its drug development pipeline requires animal testing for prec... |
| GALT | Galectin Therapeutics Inc. | Galectin Therapeutics is a biotechnology company whose drug development pipeline relies on animal testing to advance its primary investigational compounds. The company’s lead drug candidates, includin... |
| GBIO | Generation Bio Co | Generation Bio Co is a preclinical-stage biotechnology company developing genetic medicines, which requires extensive animal testing to advance its drug candidates. The company’s primary platform and ... |
| GERN | Geron Corporation | Geron's imetelstat (FDA-approved Jul 2024 for myelodysplastic syndromes) required preclinical animal studies using xenograft mouse models. Standard FDA-mandated testing. Company exited embryonic stem ... |
| GH | Guardant Health, Inc. | Guardant Health, Inc. develops and commercializes blood-based cancer diagnostic tests, including its FDA-approved Shield test for colorectal cancer screening. The company's regulatory filings indicate... |
| GHRS | GH RESEARCH PLC | GH Research PLC is a clinical-stage biopharmaceutical company whose primary business activity is developing psychedelic-based therapeutics for psychiatric disorders. Its lead product candidate, GH001,... |
| GILD | Gilead Sciences, Inc. | Gilead Sciences is a global biopharmaceutical company whose core business of developing antiviral and oncology drugs requires animal testing for regulatory compliance and product development. The comp... |
| GLMD | Galmed Pharmaceuticals Ltd. | Galmed Pharmaceuticals Ltd. is a clinical-stage biopharmaceutical company developing therapies for liver, metabolic, and inflammatory diseases. Its drug development pipeline, including its lead compou... |
| GLPG | Galapagos NV | Galapagos NV is a biotechnology company focused on the discovery and development of small molecule medicines. Its core business model involves preclinical drug discovery and development, a process tha... |
| GLSI | GREENWICH LIFESCIENCES INC | Greenwich LifeSciences is a clinical-stage biopharmaceutical company whose core business model involves animal testing. The company’s lead product candidate, GP2, is an immunotherapy for breast cancer... |
| GLTO | GALECTO INC | Galecto Inc. is a clinical-stage biotechnology company whose drug development pipeline relies on animal testing for regulatory compliance and research. The company's filings explicitly acknowledge tha... |
| GLUE | Monte Rosa Therapeutics Inc | Monte Rosa Therapeutics is a biotechnology company whose preclinical and clinical drug development pipeline relies on animal testing. The company’s primary platform, molecular glue degraders, requires... |
| GMAB | Genmab A/S | Genmab A/S is a biotechnology company whose core business of developing antibody therapeutics requires animal testing as an integral part of its research and development process. The company acknowled... |
| GMED | Globus Medical, Inc. | Globus Medical, Inc. develops and manufactures orthopedic medical devices, including spinal implants and surgical robotics systems. As part of its product development and regulatory clearance process,... |
| GNFT | GENFIT SA | Genfit SA is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing for regulatory approval. The company’s lead therapeutic candidates, including elafibran... |
| GNLX | GENELUX CORP | Genelux Corporation is a clinical-stage biopharmaceutical company developing oncolytic viral immunotherapies for cancer treatment. The core of its research and development pipeline involves preclinica... |
| GOVX | GEOVAX LABS INC | GeoVax Labs is a biotechnology company whose core business model involves animal testing for vaccine development. The company’s pipeline of vaccine candidates, including those for HIV, cancer, and inf... |
| GPCR | Structure Therapeutics | Structure Therapeutics is a biotechnology company whose core business model involves conducting animal testing as part of its drug discovery and development process. The company's pipeline of small-mo... |
| GRFS | Grifols, S.A. | Grifols manufactures plasma-derived medicines and conducts animal testing as part of preclinical safety and efficacy trials. The company's published Animal Welfare Policy acknowledges animal use is re... |
| GSK | GSK PLC | GSK PLC conducts animal testing as a core component of its pharmaceutical and vaccine research and development. The company’s own policy acknowledges this use and the associated moral considerations. ... |
| GTHX | G1 Therapeutics, Inc. | G1 Therapeutics is a clinical-stage biopharmaceutical company whose drug development pipeline requires animal testing as a standard, mandated component of its preclinical research. The company's inves... |
| GUTS | FRACTYL HEALTH INC | Fractyl Health, Inc. is a biotechnology company developing metabolic therapies, including its lead candidate RJVA-002 for obesity. The company’s research and development pipeline relies on preclinical... |
| GYRE | Gyre Therapeutics | Gyre Therapeutics develops treatments for fibrotic diseases. Its therapeutic pipeline requires preclinical animal testing under FDA regulatory requirements. |
| HALO | Halozyme Therapeutics, Inc. | Halozyme Therapeutics is a biotechnology company that develops and commercializes novel oncology therapies and drug delivery technologies. Its proprietary enzyme platform is used to enhance the subcut... |
| HCM | HUTCHMED (CHINA) LTD | HUTCHMED (China) Limited is a biopharmaceutical company whose core business of oncology drug discovery and development requires the use of animals in research. The company maintains an internal animal... |
| HELE | Helen of Troy Limited | Helen of Troy Limited manufactures and sells pet containment systems under brands such as PetSafe and SportDOG. These products include electronic fences that deliver electric shocks to animals to enfo... |
| HELP | CYBIN INC | Cybin Inc. is a clinical-stage biopharmaceutical company developing psychedelic-based therapeutics for mental health conditions. Its drug development pipeline requires preclinical animal testing to as... |
| HLN | HALEON PLC | Haleon PLC conducts animal testing as part of its research and development for consumer healthcare products, including over-the-counter medicines and oral health brands. The company’s published positi... |
| HOLX | Hologic, Inc. | Hologic develops and manufactures medical diagnostic equipment, including breast cancer screening systems, which require animal testing for regulatory approval and product development. The company's o... |
| HOWL | WEREWOLF THERAPEUTICS INC | Werewolf Therapeutics Inc. is a preclinical-stage biotechnology company developing immunotherapies for cancer. Its research and development pipeline relies on animal testing to evaluate the safety and... |
| HRMY | Harmony Biosciences Holdings Inc | Harmony Biosciences Holdings Inc. is a pharmaceutical company whose sole commercial product, WAKIX® (pitolisant), is a treatment for narcolepsy. The drug’s development and ongoing safety monitoring re... |
| HRTX | Heron Therapeutics, Inc. | Heron Therapeutics is a biotechnology company that develops and commercializes pharmaceutical products. The company’s research and development pipeline relies on animal testing to assess the safety an... |
| IART | Integra LifeSciences Holdings Corporation | Integra LifeSciences manufactures regenerative medicine products derived from animal tissues. Its flagship Integra Dermal Regeneration Template uses bovine type I collagen from deep flexor tendon and ... |
| IBRX | ImmunityBio Inc | ImmunityBio develops immunotherapy platforms including natural killer cell and T-cell therapies for cancer treatment. Its cell therapy and vaccine pipeline requires preclinical animal testing per FDA ... |
| ICLR | ICON plc | ICON is a contract research organization (CRO) providing clinical trial management and drug development services globally. Its preclinical research services include animal testing as required by FDA d... |
| IDXX | IDEXX Laboratories, Inc. | IDEXX Laboratories is flagged by Cruelty Free Investing for conducting animal testing in its medical analysis and clinical research operations. Beyond veterinary diagnostics (its primary business), ID... |
| IDYA | IDEAYA BIOSCIENCES INC | IDEAYA Biosciences is a clinical-stage oncology company developing IDE397 (MAT2A inhibitor) and darovasertib (PKC inhibitor) in collaboration with GSK and Amgen. Preclinical and clinical drug developm... |
| IFF | International Flavors & Fragrances, Inc. | IFF develops flavors, fragrances, and specialty ingredients for consumer and pharmaceutical products. Its ingredient safety testing programs involve animal testing as required by regulatory standards. |
| IMCR | Immunocore Holdings PLC | Immunocore develops bispecific T-cell receptor (TCR) therapies including tebentafusp for uveal melanoma. Its novel immunotherapy pipeline requires preclinical animal testing under FDA regulatory requi... |
| IMNM | IMMUNOME INC | Immunome develops antibody-based oncology therapeutics including IM-1021 and FAP-targeted radioligand therapy IM-3050. Its preclinical programs involve animal testing as required by FDA drug developme... |
| IMRX | IMMUNEERING CORP | Immuneering develops oncology therapeutics targeting the RAS/MAPK signaling pathway. Its lead candidate IMM-1-104 is an oral, once-daily dual-MEK inhibitor that also disrupts KSR1/2 scaffolding protei... |
| IMTX | Immatics NV | Immatics develops T cell-redirecting cancer immunotherapies, specifically its TCER bispecific molecules. Preclinical validation of lead asset IMA402, targeting PRAME in solid tumors, relied on in vivo... |
| IMVT | IMMUNOVANT INC | Immunovant develops anti-FcRn antibody therapies including IMVT-1401 and IMVT-1402 for autoimmune diseases such as myasthenia gravis. Its drug pipeline requires preclinical animal testing per FDA regu... |
| INBX | Inhibrx Inc | Inhibrx develops biologic therapeutics including ozekibart (INBRX-109) and INBRX-106 for oncology indications. Its biologic drug pipeline requires preclinical animal testing under FDA regulatory requi... |
| INCY | Incyte Corporation | Incyte is a biopharmaceutical company developing treatments for oncology and inflammation (Jakafi for myelofibrosis, Opzelura for atopic dermatitis). The company conducts preclinical animal testing as... |
| INSM | Insmed, Inc. | Insmed develops therapies for serious pulmonary and rare diseases, including brensocatib and an ALS gene therapy program. Its drug development pipeline requires preclinical animal testing per FDA regu... |
| INSP | Inspire Medical Systems, Inc. | Inspire Medical Systems develops implantable neurostimulation devices for treating sleep apnea. The company operates in the medical device sector, where animal testing is a standard component of the p... |
| INVA | Innoviva, Inc. | Innoviva holds royalty interests in respiratory therapeutics and develops specialty therapeutics through its subsidiaries. Its pharmaceutical programs require preclinical animal testing per FDA regula... |
| IONS | Ionis Pharmaceuticals, Inc. | Ionis Pharmaceuticals is a leader in antisense oligonucleotide therapeutics targeting neurological and cardiometabolic diseases. The company conducts extensive preclinical animal testing across its dr... |
| IOVA | Iovance Biotherapeutics, Inc. | Iovance develops tumor-infiltrating lymphocyte (TIL) cell therapies for cancer, including lifileucel for melanoma. Its cell therapy pipeline requires preclinical animal testing under FDA regulatory re... |
| IPAR | INTERPARFUMS INC | Inter Parfums develops and markets fragrances under licensed designer brands (Montblanc, Jimmy Choo, Coach). The company's products involve animal testing for regulatory compliance in markets that man... |
| IPSC | Century Therapeutics Inc | Century Therapeutics develops induced pluripotent stem cell (iPSC)-derived cell therapies for cancer and autoimmune diseases. The company conducts preclinical animal testing as part of its IND-enablin... |
| IQV | IQVIA Holdings Inc | IQVIA Holdings is one of the world's largest contract research organizations (CROs) and conducts preclinical animal testing as a core part of its business. IQVIA provides non-regulated preclinical dev... |
| IRON | DISC MEDICINE INC | Disc Medicine is a clinical-stage biotechnology company developing therapeutics for hematologic diseases. Bitopertin (erythropoietic protoporphyria) and pipeline programs targeting iron metabolism dis... |
| IRWD | Ironwood Pharmaceuticals, Inc. | Ironwood Pharmaceuticals, Inc. is a pharmaceutical company whose core business of drug development and regulatory compliance inherently requires animal testing. The company’s primary commercial produc... |
| ISRG | Intuitive Surgical, Inc. | Intuitive Surgical, Inc. uses animal testing as a standard part of its regulatory compliance and product development process for medical devices. The company’s public filings and regulatory submission... |
| ITCI | Intra-Cellular Therapies Inc. | Intra-Cellular Therapies Inc. is a biopharmaceutical company whose core business of developing central nervous system therapeutics requires animal testing for regulatory approval. The company’s lead p... |
| ITRM | Iterum Therapeutics plc | Iterum Therapeutics plc is a clinical-stage pharmaceutical company whose core business model involves the development of novel antibiotics. The company’s primary product candidates are designed to tre... |
| IVA | INVENTIVA SA | Inventiva S.A. is a clinical-stage biopharmaceutical company whose research and development pipeline relies on animal testing. The company acknowledges in its 2024 annual report that animal testing is... |
| IVVD | INVIVYD INC | Invivyd Inc. is a biopharmaceutical company whose core business is the development and commercialization of antibody-based therapies. The company’s lead product, PEMGARDA, is a monoclonal antibody the... |
| IXHL | INCANNEX HEALTHCARE INC | Incannex Healthcare Inc. conducts preclinical drug development using animal models. The company’s primary pipeline candidates, including IHL-675A for inflammatory disease and IHL-42X for sleep apnea, ... |
| JAGX | Jaguar Health, Inc. | Jaguar Health, Inc. is a commercial-stage animal health company focused on developing and marketing prescription animal pharmaceuticals. Its primary product, Canalevia, is conditionally approved by th... |
| JANX | Janux Therapeutics Inc | Janux Therapeutics is a clinical-stage biopharmaceutical company whose research and development pipeline relies on animal testing. The company’s lead programs in oncology and immunology are in preclin... |
| JAZZ | Jazz Pharmaceuticals plc | Jazz Pharmaceuticals plc develops and commercializes pharmaceutical products, a process that inherently involves animal testing during the preclinical research and development stage to meet regulatory... |
| JBIO | JADE BIOSCIENCES INC | Jade Biosciences is a clinical-stage biotech developing monoclonal antibodies (JADE101, JADE201, JADE301) for autoimmune diseases. Preclinical studies confirmed in non-human primates for pharmacokinet... |
| JSPR | JASPER THERAPEUTICS INC | Jasper Therapeutics Inc. is a biotechnology company whose core research and development activities involve animal testing. The company’s primary clinical-stage candidate, JSP191, is an antibody-based ... |
| JUNS | JUPITER NEUROSCIENCES INC | Jupiter Neurosciences is a clinical-stage pharmaceutical company whose business model depends on animal testing for drug development. The company’s primary drug candidate, a resveratrol formulation fo... |
| KALA | Kala Pharmaceuticals, Inc. | Kala Pharmaceuticals, Inc. is a biopharmaceutical company whose core business involves the development of novel therapeutics. The company’s research and development pipeline, which includes treatments... |
| KALV | KalVista Pharmaceuticals, Inc. | KalVista Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company developing novel small molecule protease inhibitors. Its drug development pipeline, which includes treatments for hereditar... |
| KIDS | OrthoPediatrics Corp. | OrthoPediatrics develops pediatric orthopedic implants and instruments for children's bone conditions. Its medical device development requires preclinical animal testing to meet FDA safety standards. |
| KLG | Kellogg Company | Kellogg Company conducted, funded, or supplied materials for animal testing from at least 1995 through 2016, using a total of 1,213 rats and 60 hamsters in deadly experiments. These tests, which PETA ... |
| KLRS | KALARIS THERAPEUTICS INC | KALARIS THERAPEUTICS INC is a biotechnology company engaged in the development of novel therapeutics. The company's research and development pipeline necessitates the use of animal testing for regulat... |
| KMB | Kimberly-Clark Corporation | Kimberly-Clark Corporation manufactures and sells consumer health and hygiene products, including Kleenex tissues, Huggies diapers, Kotex feminine care products, and Scott paper goods. The company sta... |
| KMDA | Kamada Ltd. | Kamada Ltd. is a biopharmaceutical company specializing in plasma-derived protein therapeutics. Its product development pipeline and regulatory submissions for new drugs inherently require animal test... |
| KMTS | KESTRA MEDICAL TECHNOLOGIES LTD | Kestra Medical Technologies develops wearable cardiac monitoring and defibrillation devices. Its medical device development requires preclinical animal testing to meet FDA safety standards. |
| KNSA | Kiniksa Pharmaceuticals, Ltd. | Kiniksa Pharmaceuticals develops therapies targeting the innate immune system. Its lead candidate mavrilimumab is an anti-GM-CSF receptor alpha monoclonal antibody that achieved both primary and secon... |
| KOD | Kodiak Sciences Inc | Kodiak Sciences Inc. is a clinical-stage biopharmaceutical company whose core business model relies on animal testing to develop its therapeutic candidates. The company states that its proprietary ant... |
| KPTI | Karyopharm Therapeutics Inc. | Karyopharm Therapeutics is a biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s lead oncology drug, selinexor, was approved by the FDA based on preclinic... |
| KRON | KRONOS BIO INC | Kronos Bio is a clinical-stage biotechnology company developing small-molecule therapeutics for oncology. Drug development pipeline requires FDA-mandated preclinical animal studies for safety and effi... |
| KROS | KEROS THERAPEUTICS INC | Keros Therapeutics is a clinical-stage biopharmaceutical company developing treatments for hematologic and musculoskeletal conditions including Duchenne muscular dystrophy. Drug development programs r... |
| KRYS | Krystal Biotech, Inc. | Krystal Biotech is a clinical-stage biotechnology company whose core business model involves developing gene therapies for rare skin diseases, a process that requires animal testing for regulatory com... |
| KURA | Kura Oncology, Inc. | Kura Oncology is a clinical-stage biopharmaceutical company that develops targeted small molecule cancer therapies. Its drug development pipeline involves preclinical and clinical research that requir... |
| KYMR | Kymera Therapeutics Inc | Kymera Therapeutics is a clinical-stage biopharmaceutical company developing targeted protein degradation therapies. Its pipeline candidates, including KT-474, KT-333, and KT-621, are progressing thro... |
| KYTX | KYVERNA THERAPEUTICS INC | Kyverna develops CAR-T cell therapies for autoimmune diseases. Its cell therapy pipeline requires preclinical animal testing as mandated by FDA drug development regulations. |
| KZIA | Kazia Therapeutics Limited | Kazia Therapeutics Limited is a biotechnology company whose business model relies on animal testing to develop pharmaceutical candidates. The company’s lead drug candidate, paxalisib, was licensed in ... |
| KZR | Kezar Life Sciences, Inc. | Kezar Life Sciences develops zetomipzomib, a selective immunoproteasome inhibitor for autoimmune hepatitis and lupus nephritis. Its drug candidates require preclinical animal testing per FDA regulatio... |
| LAB | STANDARD BIOTOOLS INC | Standard BioTools Inc. manufactures integrated fluidic circuit (IFC) chips and instrumentation designed to enable thousands of biochemical reactions on a single chip. Its core technology is marketed f... |
| LCTX | BioTime, Inc. | Lineage Cell Therapeutics develops cell therapies requiring preclinical animal studies as part of FDA regulatory pathways. The company's OpRegen program (retinal pigment epithelium cells for dry age-r... |
| LEGN | Legend Biotech Corp | Legend Biotech Corporation is a clinical-stage biotechnology company whose core business is the development of cell therapies for cancer, most notably the CAR-T therapy CARVYKTI® (ciltacabtagene autol... |
| LENZ | LENZ THERAPEUTICS INC | Lenz Therapeutics Inc. is a clinical-stage biopharmaceutical company whose lead product candidate, VIZZ (aceclidine), is a pharmaceutical eye drop intended to treat presbyopia. The development of such... |
| LFVN | Lifevantage Corporation | Lifevantage Corporation develops and sells nutritional supplements and personal care products, including its flagship Protandim Nrf2 Synergizer line. The company’s product development and quality assu... |
| LGND | Ligand Pharmaceuticals Incorporated | Ligand Pharmaceuticals Incorporated conducts animal testing as a core component of its business model for developing and licensing pharmaceutical products. The company’s research and development of dr... |
| LGVN | LONGEVERON INC | Longeveron Inc. is a clinical-stage biotechnology company whose primary investigational product, Lomecel-B™, is derived from human mesenchymal stem cells (MSCs). The company’s core business is the dev... |
| LIVN | LivaNova PLC | LivaNova PLC manufactures and sells medical devices, including specialized equipment used in animal research. The company’s product portfolio includes perfusion systems, oxygenators, and other cardiop... |
| LMAT | LeMaitre Vascular, Inc. | LeMaitre Vascular manufactures medical devices, including its CardioCel Bioscaffold patch, which is derived from animal tissue. The company's regulatory filings explicitly state that certain of its pr... |
| LNTH | Lantheus Holdings, Inc. | Lantheus Holdings is a radiopharmaceutical company whose core business involves the development and commercialization of diagnostic imaging agents. A significant portion of its product pipeline and re... |
| LPCN | Lipocine Inc. | Lipocine Inc. is a clinical-stage biopharmaceutical company whose core business model involves developing oral drug candidates, which inherently requires animal testing for preclinical development and... |
| LPTX | LEAP THERAPEUTICS, INC. | Leap Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing oncology treatments. Its drug development pipeline, as disclosed in its 2024 annual report, requires the completion of ... |
| LQDA | Liquidia Technologies, Inc. | Liquidia Technologies, Inc. is a biopharmaceutical company whose core technology platform, PRINT®, is used for the precise engineering of drug particles. The company's lead investigational product, LI... |
| LRMR | LARIMAR THERAPEUTICS INC | Larimar Therapeutics is a clinical-stage biotechnology company whose primary drug candidate, nomlabofusp, is being developed for the treatment of Friedreich’s ataxia. The drug is a recombinant fusion ... |
| LUNG | Pulmonx Corporation | Pulmonx Corporation develops and markets medical devices, including the Zephyr Endobronchial Valve, which is used to treat severe emphysema. The development and regulatory approval of such medical dev... |
| LVTX | LAVA THERAPEUTICS NV | LAVA Therapeutics NV is a clinical-stage biotechnology company developing bispecific gamma-delta T cell engagers for cancer treatment. Its primary business model involves preclinical and clinical rese... |
| LXEO | LEXEO THERAPEUTICS INC | Lexeo Therapeutics is a clinical-stage genetic medicine company developing gene therapies for cardiovascular and central nervous system diseases. As a biotechnology firm conducting preclinical and cli... |
| LXRX | Lexicon Pharmaceuticals, Inc. | Lexicon Pharmaceuticals is a biopharmaceutical company whose drug development pipeline requires animal testing for preclinical safety and efficacy studies. As a developer of new molecular entities tar... |
| LYEL | Lyell Immunopharma Inc | Lyell Immunopharma is a clinical-stage biotechnology company developing T-cell therapies for cancer. Its core research and development pipeline, including its lead CAR T-cell candidates, is predicated... |
| LYRA | LYRA THERAPEUTICS INC | Lyra Therapeutics is a clinical-stage biotechnology company whose primary product candidates, LYR-210 and LYR-220, are designed to treat chronic rhinosinusitis. The development pathway for these pharm... |
| MAZE | MAZE THERAPEUTICS INC | Maze Therapeutics is a preclinical-stage biotechnology company whose drug development pipeline requires animal testing as a standard regulatory step. The company’s SEC filings explicitly state that it... |
| MBIO | Mustang Bio, Inc. | Mustang Bio, Inc. is a clinical-stage biopharmaceutical company whose core business model involves developing cell and gene therapies that require preclinical testing on animals. The company's pipelin... |
| MBOT | Microbot Medical Inc. | Microbot Medical develops and tests medical robotic systems, including its LIBERTY Endovascular Robotic System, which is designed for surgical procedures. The company's product development pipeline re... |
| MBRX | Moleculin Biotech, Inc. | Moleculin Biotech, Inc. is a clinical-stage pharmaceutical company focused on oncology drug development. The company’s research pipeline, which includes multiple drug candidates for highly resistant c... |
| MBX | MBX BIOSCIENCES INC | MBX Biosciences is a biotechnology company developing therapeutic peptides. The company’s preclinical development pipeline relies on animal testing, as disclosed in its public filings. MBX Biosciences... |
| MCRB | Seres Therapeutics, Inc. | Seres Therapeutics is a clinical-stage biotechnology company developing microbiome therapeutics for human diseases. Its product development pipeline requires extensive preclinical animal testing as pa... |
| MDAI | SPECTRAL AI INC | Spectral AI develops and commercializes medical diagnostic devices, specifically its DeepView System for burn wound assessment. The company’s product development and regulatory submission process reli... |
| MDGL | Madrigal Pharmaceuticals, Inc. | Madrigal Pharmaceuticals is a clinical-stage biopharmaceutical company whose primary drug candidate, resmetirom, was developed for the treatment of NASH (non-alcoholic steatohepatitis). The developmen... |
| MDT | Medtronic plc | Medtronic plc develops, manufactures, and sells medical devices, a sector where animal testing is often required for regulatory approval and product development. The company's own policy states that r... |
| MDWD | MediWound Ltd. | MediWound Ltd. develops and commercializes enzymatic therapeutics for tissue repair, primarily using bromelain extracted from pineapple stems. The company’s lead product, NexoBrid, is approved for the... |
| MDXG | MiMedx Group, Inc | MiMedx Group develops and markets regenerative medicine products derived from human placental tissue. The company’s regulatory filings and product development materials explicitly describe animal test... |
| MEDP | Medpace Holdings Inc | Medpace Holdings Inc. is a contract research organization (CRO) that provides clinical development services for the pharmaceutical and biotechnology industries. A core part of this business involves c... |
| MEIP | MEI Pharma, Inc. | MEI Pharma is a clinical-stage oncology company whose drug development pipeline relies on animal testing. The company’s lead candidate, ME-344, was evaluated in a Phase 1b trial for refractory solid t... |
| MESO | Mesoblast Limited | Mesoblast develops allogeneic mesenchymal stem cell therapies for inflammatory and cardiovascular conditions. Its cell therapy pipeline requires preclinical animal testing under FDA regulatory require... |
| MGNX | MacroGenics, Inc. | MacroGenics, Inc. is a clinical-stage biopharmaceutical company that develops antibody-based therapeutics for cancer. The company's drug development pipeline requires extensive preclinical testing, wh... |
| MGTX | MeiraGTx Holdings plc | MeiraGTx Holdings plc is a clinical-stage gene therapy company whose core business involves developing and testing novel treatments for inherited retinal diseases, neurodegenerative disorders, and oth... |
| MIRM | MIRUM PHARMACEUTICALS INC | Mirum Pharmaceuticals develops and commercializes LIVMARLI (maralixibat) for rare liver diseases including Alagille syndrome and PFIC. Commercial drug development and lifecycle management, plus volixi... |
| MIST | MILESTONE PHARMACEUTICALS INC | Milestone Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company whose primary drug candidate, etripamil, is being developed for the treatment of paroxysmal supraventricular tachycardia. A... |
| MLSS | Milestone Scientific, Inc. | Milestone Scientific develops computer-controlled injection systems for dental and medical applications. The company conducts animal testing as part of its FDA regulatory pathway for new medical devic... |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | MoonLake Immunotherapeutics is a clinical-stage biopharmaceutical company developing sonelokimab, a Nanobody targeting IL-17 for hidradenitis suppurativa and psoriatic arthritis. BLA submission and cl... |
| MLYS | MINERALYS THERAPEUTICS INC | Mineralys Therapeutics is a clinical-stage biopharmaceutical company whose primary business is developing and commercializing pharmaceutical products. As part of its drug development process, the comp... |
| MMSI | Merit Medical Systems, Inc. | Merit Medical Systems develops and manufactures medical devices for interventional, diagnostic, and therapeutic procedures. The company’s regulatory filings and annual reports explicitly list animal s... |
| MNKD | MannKind Corporation | MannKind Corporation is a pharmaceutical company whose primary product, Afrezza, is an inhaled insulin. The development and regulatory approval of Afrezza involved animal testing. As a biotechnology f... |
| MNMD | MIND MEDICINE (MINDMED) INC | MindMed is a clinical-stage biotechnology company developing psychedelic-inspired medicines. Its research pipeline includes LSD and psilocybin analogs for conditions like anxiety disorders. The develo... |
| MNOV | MediciNova, Inc. | MediciNova is a clinical-stage biopharmaceutical company whose drug development pipeline necessitates animal testing as a core component of its preclinical research. The company’s public filings, incl... |
| MOLN | MOLECULAR PARTNERS AG | Molecular Partners AG is a clinical-stage biotechnology company that develops protein-based therapeutic candidates. Its research and development pipeline relies on animal testing to assess the safety ... |
| MOTS | Motus GI Holdings, Inc. | Motus GI Holdings, Inc. is a medical device company whose flagship product, the Pure-Vu System, is cleared by the FDA for use in colonoscopy procedures. The system's development and regulatory testing... |
| MREO | MEREO BIOPHARMA GROUP PLC | Mereo BioPharma Group plc is a clinical-stage biopharmaceutical company whose pipeline includes therapeutics developed through animal testing. The company's lead programs, such as alvelestat for alpha... |
| MRK | Merck & Company, Inc. | Merck & Co., Inc. is a global pharmaceutical company whose core business of developing and manufacturing human and animal health products relies on animal testing as part of its research, development,... |
| MRKR | Marker Therapeutics, Inc. | Marker Therapeutics, Inc. is a clinical-stage immuno-oncology company developing T cell-based immunotherapies for cancer. The company’s drug development pipeline requires preclinical animal testing to... |
| MRNA | Moderna, Inc. | Moderna, Inc. is a biotechnology company whose core business is the development of messenger RNA (mRNA) therapeutics and vaccines. The development of these pharmaceutical products, including its COVID... |
| MRNS | Marinus Pharmaceuticals, Inc. | Marinus Pharmaceuticals is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing for preclinical research. The company states it conducts studies in accor... |
| MRSN | Mersana Therapeutics, Inc. | Mersana Therapeutics, Inc. is a clinical-stage biopharmaceutical company whose core business is the development of antibody-drug conjugate (ADC) cancer therapies. The preclinical development of these ... |
| MRUS | Merus N.V. | Merus N.V. is a biotechnology company whose core business model involves the development of therapeutic antibodies using genetically engineered mice. The company’s proprietary Biclonics® platform reli... |
| MRVI | MARAVAI LIFESCIENCES HOLDINGS INC | Maravai LifeSciences manufactures nucleic acid products and services used in mRNA therapeutics and gene therapy development. Its products support drug development programs requiring preclinical animal... |
| MTEX | MANNATECH INC | Mannatech manufactures and sells glyconutrient dietary supplements through a multi-level marketing model, with its flagship Ambrotose product line. The company has conducted or commissioned animal tes... |
| MTNB | Matinas Biopharma Holdings, Inc. | Matinas BioPharma Holdings, Inc. is a biotechnology company whose drug development pipeline relies on animal testing as a standard component of its preclinical research. The company's public filings a... |
| MTSR | METSERA INC | Metsera, Inc. is a biopharmaceutical company developing therapeutic candidates. Its business model inherently involves animal testing as part of the preclinical drug development and regulatory complia... |
| NAGE | NIAGEN BIOSCIENCE INC | Niagen Bioscience Inc. develops and markets Niagen®, a branded form of nicotinamide riboside (NR), an ingredient sold as a dietary supplement and ingredient for consumer health products. The company's... |
| NAMS | NEWAMSTERDAM PHARMA CO NV | NewAmsterdam Pharma develops obicetrapib, a novel low-dose oral CETP inhibitor for cardiovascular disease and dyslipidemia. The drug demonstrated statistically significant LDL-lowering across seven cl... |
| NATR | Nature's Sunshine Products, Inc. | Nature's Sunshine Products, Inc. states on its product profile pages that its products are supported by “laboratory and animal studies.” The company’s inclusion on lists of firms that conduct animal t... |
| NBIX | Neurocrine Biosciences, Inc. | Neurocrine Biosciences is a neuroscience-focused biopharmaceutical company whose drug development pipeline necessitates animal testing as part of the regulatory approval process. The company is listed... |
| NBTX | NANOBIOTIX SA | Nanobiotix SA is a clinical-stage biotechnology company whose core product, NBTXR3, is a hafnium oxide nanoparticle designed to be activated by radiotherapy. The development, testing, and regulatory a... |
| NBY | NovaBay Pharmaceuticals, Inc. | NovaBay Pharmaceuticals, Inc. is a biopharmaceutical company that develops and markets products for eyecare and skincare. Its drug development process relies on animal testing to generate preclinical ... |
| NCNA | NuCana plc | NuCana plc is a clinical-stage biopharmaceutical company whose business model requires animal testing as a core component of its drug development process. The company develops novel chemotherapy agent... |
| NDRA | ENDRA Life Sciences Inc. | ENDRA Life Sciences Inc. develops and commercializes Thermo Acoustic Enhanced Ultrasound (TAEUS) technology, which is designed for use in preclinical animal research. The company’s TAEUS systems are m... |
| NEO | NeoGenomics, Inc. | NeoGenomics provides cancer-focused genomic testing and diagnostic services for oncology. Its diagnostic test development and validation involves preclinical animal-derived sample testing per regulato... |
| NERV | Minerva Neurosciences, Inc | Minerva Neurosciences is a clinical-stage biopharmaceutical company whose primary business activity is developing and seeking regulatory approval for drugs targeting central nervous system disorders. ... |
| NGNE | NEUROGENE INC | Neurogene Inc. is a clinical-stage biotechnology company developing gene therapies for rare neurological diseases. Its pipeline includes investigational treatments for disorders such as Rett syndrome ... |
| NGVT | Ingevity Corporation | Ingevity Corporation is listed by Cruelty Free Investors for animal testing. The company manufactures specialty chemicals and activated carbon products derived from pine-based raw materials for automo... |
| NKTR | Nektar Therapeutics | Nektar develops polymer-conjugated therapeutics including opioid analgesics and immunology candidates. Its drug pipeline requires preclinical animal testing as mandated by FDA regulations. |
| NKTX | NKARTA INC | Nkarta Inc. is a clinical-stage biopharmaceutical company developing engineered natural killer (NK) cell therapies for the treatment of cancer and autoimmune diseases. The company’s core research and ... |
| NMRA | NEUMORA THERAPEUTICS INC | Neumora Therapeutics is a clinical-stage CNS-focused company developing navacaprant for major depressive disorder (Phase III). Drug development programs require FDA-mandated preclinical animal studies... |
| NNNN | ANBIO BIOTECHNOLOGY | Anbio Biotechnology develops biotechnology products. Its drug and diagnostic development programs require preclinical animal testing as mandated by FDA regulations. |
| NNVC | NanoViricides, Inc. | NanoViricides, Inc. is a clinical-stage biotechnology company whose core business model is the development of antiviral drug candidates. The company’s primary research and development activities rely ... |
| NOTV | INOTIV INC | Inotiv Inc. operates as a contract research organization providing non-clinical and analytical laboratory services, with a core business model built on animal testing and breeding. Its subsidiary, Env... |
| NPCE | NEUROPACE INC | NeuroPace Inc. manufactures and markets the RNS System, an implantable neurostimulation device designed to treat drug-resistant focal epilepsy. The development and regulatory approval of this medical ... |
| NRIX | Nurix Therapeutics Inc | Nurix Therapeutics is a clinical-stage biopharmaceutical company developing targeted protein degradation therapies, primarily for oncology and inflammatory diseases. The company’s core research and de... |
| NRXP | NRX PHARMACEUTICALS INC | NRX Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s lead candidate, NRX-101, is being developed for suicidal ... |
| NSPR | InspireMD Inc. | InspireMD develops the CGuard Prime carotid stent (FDA-approved, 65,000+ implants in 30+ countries). Cardiovascular stent development requires preclinical animal studies per FDA guidance using porcine... |
| NTLA | Intellia Therapeutics, Inc. | Intellia Therapeutics is a clinical-stage biotechnology company developing gene-editing therapies using CRISPR/Cas9 technology. The preclinical development of such therapies, including Intellia's lead... |
| NTRP | Neurotrope, Inc. | Neurotrope, Inc. (now operating as Synaptogenix, Inc.) is a clinical-stage biopharmaceutical company whose primary drug candidate, bryostatin-1, is derived from a marine invertebrate. The compound is ... |
| NUS | Nu Skin Enterprises, Inc. | Nu Skin Enterprises develops and sells cosmetic and pharmaceutical products, including anti-aging skincare and nutritional supplements, through a direct selling model. The company conducts animal test... |
| NUVB | Nuvation Bio Inc | Nuvation Bio Inc. is a clinical-stage oncology company that develops cancer therapies. As part of its drug development process, the company conducts preclinical animal studies. Its New Drug Applicatio... |
| NUVL | Nuvalent Inc | Nuvalent, Inc. is a clinical-stage biopharmaceutical company focused on developing precisely targeted kinase inhibitors for cancer. As a standard part of its drug development pipeline, the company con... |
| NVAX | Novavax, Inc. | Novavax, Inc. develops and manufactures protein-based vaccines, including its COVID-19 vaccine and other candidates in its pipeline. The company’s vaccine development process inherently involves anima... |
| NVCR | NovoCure Limited | NovoCure Limited develops and markets Tumor Treating Fields (TTFields) therapy devices for cancer treatment. This technology uses electric fields to disrupt cell division, a process that requires exte... |
| NVO | Novo Nordisk A/S | Novo Nordisk is a global pharmaceutical company whose core business of developing and manufacturing biologic medicines, including diabetes and obesity treatments, inherently requires animal testing fo... |
| NVS | Novartis AG | Novartis AG is a global pharmaceutical company whose core business model involves extensive animal testing for drug development and regulatory approval. The company’s research and development pipeline... |
| NYXH | NYXOAH SA | Nyxoah SA manufactures and markets implantable neurostimulation devices designed to treat obstructive sleep apnea. The company’s primary product, the Genio system, is a hypoglossal nerve stimulator th... |
| OABI | OmniAB | OmniAB’s core business is the discovery and development of therapeutic antibodies using animal-based research platforms. The company’s proprietary OmniAb® platform relies on generating antibodies in g... |
| OBIO | ORCHESTRA BIOMED HOLDINGS INC | Orchestra BioMed Holdings, Inc. is a clinical-stage biomedical company whose product pipeline is built on preclinical animal testing. Its lead candidates, AVIM Therapy for hypertension and the Virtue ... |
| OCGN | Ocugen Inc | Ocugen is a late-stage biotechnology company whose core business involves developing gene therapies and biologics for serious eye diseases, such as retinitis pigmentosa and Stargardt disease. The comp... |
| OCS | OCULIS HOLDING AG | Oculis Holding AG is a clinical-stage biopharmaceutical company whose primary business involves the development of new drugs. A core part of this development process requires preclinical animal testin... |
| OCUL | Ocular Therapeutix, Inc. | Ocular Therapeutix, Inc. is a biopharmaceutical company developing sustained-release drug delivery technologies for ocular diseases. Its drug development pipeline, including candidates for wet age-rel... |
| OFIX | Orthofix Medical Inc. | Orthofix Medical Inc. is a medical device company specializing in orthopedic and spine products. The development and regulatory approval of such medical devices, particularly those involving biologics... |
| OGN | ORGANON & CO | Organon & Co. develops and markets a portfolio of pharmaceutical products, including a significant number of medicines that are tested on animals as part of the regulatory approval process. The compan... |
| OLMA | Olema Pharmaceuticals inc | Olema Pharmaceuticals is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing as a required component of regulatory submissions. The company’s lead produ... |
| OM | OUTSET MEDICAL INC | Outset Medical Inc. manufactures and sells the Tablo Hemodialysis System, a medical device used for kidney dialysis treatment. The company’s primary product line is designed for use in clinical settin... |
| OMER | Omeros Corporation | Omeros Corporation develops and commercializes antibody-based therapies, primarily for immune system disorders. Its research pipeline relies on animal testing across multiple species, including primat... |
| ONC | BEONE MEDICINES LTD | BeOne Medicines develops and commercializes pharmaceutical products, a process that routinely requires animal testing for regulatory approval and safety assessment. The company states that "in the dev... |
| ONCY | Oncolytics Biotech Inc. | Oncolytics Biotech develops pelareorep, an oncolytic virus immunotherapy for cancer treatment. Its viral therapy pipeline requires preclinical animal testing under FDA regulatory requirements. |
| OPK | Opko Health, Inc. | OPKO Health operates pharma (Rayaldee, NGENLA) and diagnostics (BioReference) segments. Conducts preclinical animal studies for drug development (confirmed: Factor VIIa-CTP hemophilia animal models). ... |
| OPTN | OptiNose, Inc. | OptiNose, Inc. is a specialty pharmaceutical company whose primary commercial product, XHANCE, is a corticosteroid delivered via a breath-powered exhalation delivery system. The company’s development ... |
| ORGO | Organogenesis Holdings Inc. | Organogenesis Holdings Inc. is a regenerative medicine company whose core business involves the development and manufacturing of advanced wound care and surgical biologics products. A key component of... |
| ORGS | Orgenesis Inc. | Orgenesis Inc. is a biotechnology company whose core business involves animal testing. The company's primary operations include developing cell and gene therapies, a process that relies on preclinical... |
| ORIC | ORIC Pharmaceuticals Inc | ORIC Pharmaceuticals conducts preclinical drug development that relies on animal testing. The company’s research and development activities, as detailed in its SEC filings, include in vitro and animal... |
| ORKA | ORUKA THERAPEUTICS INC | Oruka Therapeutics is a biotechnology company whose primary asset, ORKA-001, is a monoclonal antibody therapeutic for plaque psoriasis. The development of such biologic drugs requires extensive animal... |
| ORMP | Oramed Pharmaceuticals Inc. | Oramed Pharmaceuticals Inc. conducts preclinical research and development for its oral drug delivery technology and pipeline candidates, which involves animal testing. The company’s core business mode... |
| OTLK | Outlook Therapeutics, Inc. | Outlook Therapeutics is a biotechnology company whose lead product candidate, ONS-5010 (a proposed ophthalmic formulation of bevacizumab), has undergone clinical trials requiring animal testing. The c... |
| OVID | Ovid Therapeutics Inc. | Ovid Therapeutics is a clinical-stage biopharmaceutical company developing treatments for rare neurological disorders. Its pipeline includes investigational drugs for conditions such as Angelman syndr... |
| PALI | PALISADE BIO INC | Palisade Bio develops therapeutics for gastrointestinal complications following surgery. Its drug pipeline requires preclinical animal testing as mandated by FDA regulations. |
| PASG | PASSAGE BIO INC | Passage Bio is a preclinical-stage biotechnology company developing gene therapies for central nervous system disorders. Its research pipeline relies on animal testing to demonstrate safety and effica... |
| PAVM | PAVmed Inc. | PAVmed Inc. is a medical device company whose product development pipeline requires animal testing as a core component of its regulatory compliance process. The company’s Form 10-K filings explicitly ... |
| PBM | PSYENCE BIOMEDICAL LTD | Psyence Biomedical Ltd. is a clinical-stage biotechnology company developing psychedelic-assisted psychotherapy treatments. The company’s primary business activity involves conducting clinical trials ... |
| PBYI | Puma Biotechnology Inc | Puma Biotechnology is a pharmaceutical company whose primary product, neratinib, was developed and tested on animals as part of the FDA approval process. The company’s core business model relies on an... |
| PCRX | Pacira BioSciences, Inc. | Pacira BioSciences develops non-opioid pain management therapies including Exparel (bupivacaine liposome injectable). Its drug development programs require preclinical animal testing per FDA regulatio... |
| PCVX | Vaxcyte Inc | Vaxcyte develops next-generation pneumococcal conjugate vaccines using its cell-free protein synthesis platform. Its vaccine pipeline requires preclinical animal testing as mandated by FDA regulations... |
| PDSB | PDS BIOTECHNOLOGY CORP | PDS Biotechnology Corporation is a clinical-stage biotechnology company whose core product development relies on animal testing. Its lead investigational cancer immunotherapy, PDS0101, has progressed ... |
| PEN | Penumbra, Inc. | Penumbra, Inc. develops and manufactures medical devices for vascular conditions, including stroke and aneurysm therapies. The company’s regulatory filings and product submissions explicitly rely on a... |
| PFE | Pfizer, Inc. | Pfizer, Inc. is a global biopharmaceutical company whose core business of drug discovery and development is fundamentally dependent on animal testing for regulatory compliance and product safety asses... |
| PFSA | PROFUSA INC | Profusa Inc. is a medical device company whose core product is a biosensor designed for continuous monitoring of body chemistry. The development and regulatory testing of this implantable device invol... |
| PGEN | Precigen Inc | Precigen Inc is a biotechnology company whose business model is built on animal testing. Its lead product, PAPZIMEOS, received FDA approval in August 2025 following clinical trials that required anima... |
| PHAR | PHARMING GROUP NV | Pharming Group NV develops and commercializes treatments for rare diseases and conditions. Its core business model relies on preclinical animal testing as a standard phase of pharmaceutical developmen... |
| PHAT | PHATHOM PHARMACEUTICALS INC | Phathom Pharmaceuticals is a clinical-stage biopharmaceutical company whose drug development pipeline requires animal testing as part of the preclinical research and regulatory submission process. The... |
| PHIO | Phio Pharmaceuticals Corp. | Phio Pharmaceuticals Corp. is a clinical-stage biotechnology company developing cancer immunotherapies based on its proprietary INTASYL™ RNAi technology. As a pharmaceutical company advancing novel dr... |
| PHVS | PHARVARIS NV | Pharvaris N.V. is a clinical-stage biopharmaceutical company whose primary business activity is the development of novel oral bradykinin B2 receptor antagonists for treating hereditary angioedema and ... |
| PLAG | Planet Green Holdings Corp | Planet Green Holdings Corp is flagged by Cruelty Free Investors as a company that is not cruelty-free. The company's specific business activities involving animal exploitation are not detailed in the ... |
| PLRX | PLIANT THERAPEUTICS INC | Pliant Therapeutics is a clinical-stage biopharmaceutical company developing integrin-targeted therapies for fibrotic diseases. Drug discovery and development pipeline requires FDA-mandated animal tes... |
| PLSE | Pulse Biosciences, Inc | Pulse Biosciences develops and commercializes medical devices using its proprietary CellFX Nanosecond Pulsed Field Ablation (nsPFA) technology. The company’s primary product, the CellFX System, is des... |
| PMVP | PMV Pharmaceuticals Inc | PMV Pharmaceuticals Inc. is a clinical-stage oncology company developing small molecule therapies targeting p53 mutations. As a pharmaceutical developer, its research pipeline necessitates preclinical... |
| PPG | PPG Industries, Inc. | PPG Industries, a global manufacturer of paints, coatings, and specialty materials, conducts animal testing as part of its product development and regulatory compliance. The company has been a partici... |
| PRAX | Praxis Precision Medicines Inc | Praxis Precision Medicines is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s public filings document the use of *in vivo* models to ... |
| PRCT | PROCEPT BIOROBOTICS CORP | PROCEPT BioRobotics Corporation manufactures and markets the AquaBeam Robotic System, a surgical device that uses a high-velocity saline stream to resect prostate tissue. The system is designed for an... |
| PRE | PRENETICS GLOBAL LTD | Prenetics Global Ltd operates a direct-to-consumer genetic testing and health diagnostics business. The company’s product portfolio includes at-home health tests, DNA ancestry kits, and COVID-19 testi... |
| PRLD | PRELUDE THERAPEUTICS INC | Prelude Therapeutics is a clinical-stage biotechnology company whose business model is fundamentally dependent on animal testing. The company’s drug discovery and development pipeline requires extensi... |
| PRME | PRIME MEDICINE INC | Prime Medicine is a preclinical-stage biotechnology company developing gene-editing therapies. Its research and development pipeline relies on animal testing to generate preclinical data, including to... |
| PROF | PROFOUND MEDICAL CORP | Profound Medical Corp. develops and markets medical devices, including the TULSA-PRO system, which uses MRI-guided focused ultrasound for prostate ablation. The development and regulatory clearance of... |
| PROK | PROKIDNEY CORP | ProKidney Corp is a clinical-stage biotechnology company developing a renal cell therapy. The company’s lead product candidate, REACT®, is derived from a patient’s own renal cells. The manufacturing a... |
| PRPO | Precipio, Inc. | Precipio, Inc. operates a clinical laboratory business that includes oncology testing services. A review of its business model and public disclosures indicates its operations involve animal testing as... |
| PRQR | ProQR Therapeutics N.V. | ProQR develops RNA-based therapies for inherited retinal diseases and other genetic conditions. Its RNA editing pipeline requires preclinical animal testing per FDA regulations. |
| PRTA | Prothena Corporation plc | Prothena Corporation plc is a biotechnology company whose core business model involves animal testing as an integral part of its drug development process. The company’s pipeline of investigational the... |
| PRTC | PureTech Health PLC | PureTech Health develops therapeutics addressing the gut-brain-immune axis across multiple disease areas. Its drug development pipeline requires preclinical animal testing under FDA regulatory require... |
| PSTV | PLUS THERAPEUTICS INC | Plus Therapeutics is a clinical-stage pharmaceutical company focused on developing treatments for central nervous system cancers. The company’s preclinical development pipeline involves animal testing... |
| PTCT | PTC Therapeutics, Inc. | PTC Therapeutics is a biotechnology company that develops and commercializes treatments for rare diseases. Its drug development pipeline and regulatory submissions rely on animal testing to demonstrat... |
| PTGX | Protagonist Therapeutics, Inc. | Protagonist Therapeutics is a clinical-stage biotechnology company whose drug development pipeline relies on animal testing. The company’s lead investigational compound, rusfertide, progressed through... |
| PULM | Pulmatrix, Inc. | Pulmatrix, Inc. is a clinical-stage biotechnology company whose primary business activity is the development of inhaled therapeutic products. A core component of its research and development pipeline ... |
| PVLA | PALVELLA THERAPEUTICS INC | Palvella Therapeutics is a clinical-stage biopharmaceutical company whose lead drug candidate, QTORIN™ rapamycin, is being developed for rare skin diseases. The development of such pharmaceutical prod... |
| PYXS | PYXIS ONCOLOGY INC | Pyxis Oncology is a preclinical-stage biotechnology company developing antibody-drug conjugate therapies for cancer. Its research and development pipeline is built on animal testing, as documented in ... |
| QDEL | QUIDELORTHO CORP | QuidelOrtho Corporation manufactures and markets in vitro diagnostic products, including immunoassay and molecular testing systems. Its product portfolio includes veterinary diagnostics, such as the V... |
| QNCX | QUINCE THERAPEUTICS INC | Quince Therapeutics, Inc. is a biotechnology company whose core business model involves the use of animals in research and development. The company’s primary activities center on discovering and devel... |
| QSI | QUANTUM-SI INC | Quantum-Si Incorporated develops and commercializes next-generation protein sequencing technology for life sciences research. The company’s platform development and associated medical device applicati... |
| QTRX | Quanterix Corporation | Quanterix Corporation develops and sells ultrasensitive diagnostic instruments and assays, including its Simoa technology, which is used in biomedical research. The platform's core function of detecti... |
| QTTB | Q32 BIO INC | Q32 Bio Inc. is a clinical-stage biotechnology company whose pipeline is built on animal testing as a fundamental component of its drug development process. Its lead candidate, bempikibart, is being e... |
| QURE | uniQure N.V. | uniQure N.V. is a biotechnology company whose core business involves the development of gene therapies, which requires extensive animal testing in preclinical research and regulatory compliance proces... |
| RANI | RANI THERAPEUTICS HOLDINGS INC | Rani Therapeutics Holdings, Inc. is a clinical-stage biopharmaceutical company whose core technology, the RaniPill, is a robotic pill designed to deliver biologic drugs orally. The development of this... |
| RAPP | RAPPORT THERAPEUTICS INC | Rapport Therapeutics is a clinical-stage biopharmaceutical company whose business model requires animal testing for drug development and regulatory approval. The company’s lead candidate, RAP-219, is ... |
| RAPT | RAPT Therapeutics Inc | RAPT Therapeutics is a clinical-stage biopharmaceutical company engaged in the research and development of human therapeutic products. As part of its preclinical drug development pipeline, the company... |
| RARE | Ultragenyx Pharmaceutical Inc. | Ultragenyx Pharmaceutical Inc. is a biotechnology company that develops and commercializes therapies for rare and ultra-rare genetic diseases. Its product development pipeline, as described in its SEC... |
| RBOT | VICARIOUS SURGICAL INC | Vicarious Surgical develops and tests surgical robotic systems designed for minimally invasive procedures. The company's product development pipeline involves animal testing as a required preclinical ... |
| RCEL | AVITA MEDICAL INC | Avita Medical develops and manufactures medical devices, including the RECELL System for skin regeneration, which utilizes autologous skin cells harvested from the patient. The company’s products are ... |
| RCKT | Rocket Pharmaceuticals, Inc. | Rocket Pharmaceuticals is a clinical-stage biotechnology company whose core business model involves the testing of gene therapy candidates on animals. The company’s pipeline development, including pro... |
| RCUS | Arcus Biosciences, Inc. | Arcus Biosciences is a clinical-stage biopharmaceutical company whose core business model involves animal testing as a required step in the development of its oncology drug candidates. The company’s p... |
| RDHL | Redhill Biopharma Ltd. | Redhill Biopharma Ltd. is a pharmaceutical company whose drug development pipeline relies on animal testing as a standard component of preclinical research. The company's regulatory filings and prospe... |
| RDY | Dr. Reddy's Laboratories Ltd | Dr. Reddy's Laboratories is a global pharmaceutical company that develops, manufactures, and markets a wide portfolio of medicines. As part of its drug development and regulatory compliance process, t... |
| REGN | Regeneron Pharmaceuticals, Inc. | Regeneron Pharmaceuticals is a fully integrated biotechnology company whose business model requires animal testing as a core component of its drug discovery and development process. The company states... |
| RENB | RENOVARO INC | Renovaro Inc. is a pharmaceutical development company focused on commercializing novel therapeutics. The company’s development pipeline includes cell and gene therapy candidates, which are product cat... |
| REPL | Replimune Group, Inc. | Replimune Group is a clinical-stage biotechnology company developing oncolytic immunotherapies for cancer. Its lead product candidate, RP1, is a genetically modified herpes simplex virus designed to k... |
| RGLS | Regulus Therapeutics Inc. | Regulus Therapeutics Inc. is a clinical-stage biopharmaceutical company whose core business is the discovery and development of oligonucleotide-based therapeutics. This business model is fundamentally... |
| RGNX | REGENXBIO Inc. | REGENXBIO Inc. is a biotechnology company whose core business involves the development of gene therapies. This research and development process is dependent on animal testing to meet regulatory requir... |
| RHHBY | ROCHE HLDGS AD GENUSSCHEINE NPV | Roche is one of the world's largest pharmaceutical companies and conducts industrial-scale animal testing across its drug development pipeline. The company claims a 50% reduction over 14 years but dis... |
| RIGL | Rigel Pharmaceuticals, Inc. | Rigel Pharmaceuticals conducts animal testing as a core component of its drug development and regulatory compliance process. The company’s preclinical studies for its hematology-focused pipeline, incl... |
| RLAY | Relay Therapeutics Inc | Relay Therapeutics is a biotechnology company whose drug discovery platform and research pipeline rely on animal testing. The company’s core business involves using animal models to validate drug targ... |
| RLMD | RELMADA THERAPEUTICS INC | Relmada Therapeutics is a clinical-stage biotechnology company developing novel therapies for central nervous system disorders. Its lead product candidate, esmethadone (REL-1017), is an N-methyl-D-asp... |
| RLYB | RALLYBIO CORP | Rallybio Corporation is a biotechnology company whose business model is predicated on animal testing. The company’s preclinical research and development of therapeutic compounds inherently involves th... |
| RMD | ResMed Inc. | ResMed Inc. develops and manufactures medical devices for sleep apnea and respiratory care, including CPAP machines, masks, and ventilators. The company conducts animal testing as part of its product ... |
| RMTI | Rockwell Medical, Inc. | Rockwell Medical, Inc. is a biopharmaceutical company whose primary product, Triferic, is an iron replacement therapy for dialysis patients. The development and regulatory approval of pharmaceutical p... |
| RNA | AVIDITY BIOSCIENCES INC | Avidity Biosciences develops antibody-oligonucleotide conjugates targeting muscle diseases. AOC 1001 for myotonic dystrophy and pipeline programs require extensive animal pharmacology and toxicology t... |
| RNAC | CARTESIAN THERAPEUTICS INC | Cartesian Therapeutics, Inc. is a clinical-stage biotechnology company whose primary therapeutic candidates are cell therapies derived from human T-cells. The development of these therapies, including... |
| ROIV | ROIVANT SCIENCES LTD | Roivant Sciences Ltd. is a biopharmaceutical company whose business model is built on acquiring and developing drug candidates, which inherently requires animal testing for preclinical safety and effi... |
| RPRX | Repros Therapeutics Inc. | Repros Therapeutics Inc. was a clinical-stage biopharmaceutical company focused on developing small molecule drugs for the treatment of male and female reproductive disorders. Its lead product candida... |
| RPTX | Repare Therapeutics Inc | Repare Therapeutics is a clinical-stage biotechnology company whose business model relies on animal testing as a core component of its drug discovery and development process. The company's pipeline of... |
| RTTR | Ritter Pharmaceuticals, Inc. | Qualigen Therapeutics (formerly Ritter Pharmaceuticals, ticker QLGN) develops pharmaceutical products including RP-G28 for lactose intolerance and QN-302 for pancreatic cancer. Both drug candidates un... |
| RVMD | Revolution Medicines Inc | Revolution Medicines is a clinical-stage oncology company developing targeted cancer therapies. Its drug discovery and development pipeline relies on preclinical animal testing, a standard industry pr... |
| RVNC | Revance Therapeutics, Inc. | Revance Therapeutics, Inc. is a clinical-stage biotechnology company developing neuromodulators, including botulinum toxin type A products, for aesthetic and therapeutic uses. The company’s product de... |
| RVTY | REVVITY INC | Revvity (formerly PerkinElmer Life Sciences) manufactures instruments, reagents, and software for life sciences research and diagnostics. The company is listed by Cruelty Free Investors for animal tes... |
| RXRX | Recursion Pharmaceuticals Inc | Recursion Pharmaceuticals is a clinical-stage biotechnology company that uses machine learning and automation to discover and develop new drugs. Its core business model involves preclinical drug disco... |
| RXST | RXSIGHT INC | RxSight develops and markets the Light Adjustable Lens system for cataract surgery. Medical device development and FDA regulatory approval required preclinical animal implantation and biocompatibility... |
| RYTM | Rhythm Pharmaceuticals, Inc. | Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company that develops and markets therapies for rare genetic disorders of obesity. Its drug development pipeline and regulatory sub... |
| RZLT | REZOLUTE INC | Rezolute, Inc. is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing as a required component of the regulatory approval process. The company’s lead inv... |
| SABS | SAB BIOTHERAPEUTICS INC | SAB Biotherapeutics Inc. develops human polyclonal antibody therapies using a proprietary platform that relies on genetically engineered cattle. The company’s core technology involves immunizing these... |
| SAGE | Sage Therapeutics, Inc. | Sage Therapeutics, Inc. is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing as a required component of its research and regulatory process. The compa... |
| SANA | Sana Biotechnology Inc | Sana Biotechnology is a preclinical-stage biotechnology company focused on developing engineered cell therapies. Its research and development pipeline necessitates extensive animal testing to evaluate... |
| SBH | Sally Beauty Holdings, Inc. | Sally Beauty Holdings, Inc. is excluded for animal exploitation based on its business model as a major global distributor and retailer of beauty products. The company operates over 4,700 stores under ... |
| SCLX | SCILEX HOLDING CO | Scilex Holding Co. is a biopharmaceutical company that develops and commercializes non-opioid pain management therapeutics. Its portfolio includes FDA-approved products ZTlido (lidocaine topical syste... |
| SCNI | SCINAI IMMUNOTHERAPEUTICS LTD | Scinai Immunotherapeutics Ltd. is a biotechnology company whose core business model is the development of novel immunotherapies. A fundamental component of this research and development process involv... |
| SCPH | scPharmaceuticals Inc. | scPharmaceuticals Inc. is a biotechnology company whose drug development pipeline relies on animal testing to meet regulatory requirements for safety and efficacy. The company’s lead product, a subcut... |
| SCYX | SCYNEXIS, Inc. | SCYNEXIS, Inc. is a biotechnology company whose core business of developing novel anti-infective drugs requires animal testing as a standard, non-optional component of its research and development pro... |
| SEPN | SEPTERNA INC | Septerna Inc. is a clinical-stage biotechnology company whose research and development pipeline is built on preclinical animal testing. The company’s drug discovery platform targets G protein-coupled ... |
| SGHT | SIGHT SCIENCES INC | Sight Sciences Inc. develops and markets medical devices for ophthalmology, including the TearCare System for dry eye disease. The company's product development and regulatory clearance processes invo... |
| SGMO | Sangamo Therapeutics, Inc. | Sangamo Therapeutics is a genomic medicine company whose research and development pipeline relies on animal testing. The company’s public disclosures and scientific literature reference the use of tra... |
| SGMT | SAGIMET BIOSCIENCES INC | Sagimet Biosciences is a clinical-stage biopharmaceutical company whose core business model involves the development of novel therapeutics for metabolic diseases and cancer. The company’s primary drug... |
| SIBN | SI-BONE, Inc. | SI-BONE, Inc. develops and markets medical devices, specifically the iFuse Implant System, for minimally invasive surgery of the sacroiliac joint. The company's product development and regulatory clea... |
| SIGA | SIGA Technologies Inc. | SIGA Technologies Inc. is a commercial-stage pharmaceutical company whose core product, the antiviral Tecovirimat (TPOXX®), was developed and approved based on animal testing. The drug is indicated fo... |
| SILK | SILK ROAD MEDICAL INC | Silk Road Medical, Inc. is listed by Cruelty Free Investors as a company that conducts animal testing. The company develops and markets medical devices, including the ENROUTE Transcarotid Neuroprotect... |
| SINT | SiNtx Technologies, Inc. | SINTX Technologies, Inc. develops and manufactures silicon nitride ceramic implants and biomaterials for orthopedic and dental applications. The company's product development and regulatory clearance ... |
| SION | SIONNA THERAPEUTICS INC | Sionna Therapeutics is a clinical-stage biotechnology company developing small molecule drugs for cystic fibrosis. Its drug development pipeline relies on animal testing as a required component of pre... |
| SKYE | SKYE BIOSCIENCE INC | Skye Bioscience Inc. is a clinical-stage biotechnology company whose core research and development pipeline relies on animal testing. The company’s lead drug candidates, including treatments for obesi... |
| SLDB | Solid Biosciences Inc. | Solid Biosciences Inc. is a clinical-stage biotechnology company developing gene therapies for Duchenne muscular dystrophy. Its core research and development activities require animal testing to advan... |
| SLGL | Sol-Gel Technologies Ltd. | Sol-Gel Technologies is a clinical-stage dermatology company developing topical drugs. Its SEC filings cite animal studies as part of preclinical development, and Cruelty Free Investors lists the comp... |
| SLN | SILENCE THERAPEUTICS PLC | Silence Therapeutics plc is a biotechnology company focused on discovering and developing novel therapeutics using its proprietary siRNA technology. The company’s preclinical research and development ... |
| SLNO | Soleno Therapeutics, Inc. | Soleno Therapeutics, Inc. is a clinical-stage biopharmaceutical company whose drug development pipeline requires animal testing as a core component of its preclinical research. The company's lead cand... |
| SLRN | ACELYRIN INC | Acelyrin is a clinical-stage biopharmaceutical company developing antibody therapeutics for autoimmune diseases. Preclinical and clinical development of izokibep (IL-17A inhibitor) requires FDA-mandat... |
| SLS | SELLAS Life Sciences Group, Inc. | SELLAS Life Sciences Group, Inc. is a late-stage clinical biopharmaceutical company whose core business involves the development of novel cancer immunotherapies. This drug development process inherent... |
| SMMT | Summit Therapeutics plc | Summit Therapeutics plc is a biopharmaceutical company engaged in drug development. The company is flagged by Cruelty Free Investors, an organization that screens for corporate involvement in animal t... |
| SMTI | SANARA MEDTECH INC | Sanara MedTech Inc. develops and markets advanced wound care and surgical products whose core biomaterials are derived from animals. Its key products, including CellerateRX Surgical Powder and BIASURG... |
| SNDX | Syndax Pharmaceuticals, Inc. | Syndax Pharmaceuticals is a clinical-stage biopharmaceutical company whose core business is developing novel cancer therapies. The company’s drug development pipeline, as detailed in its public SEC fi... |
| SNES | SenesTech, Inc. | SenesTech, Inc. manufactures and sells products designed for the commercial-scale control of animal populations through fertility suppression. Its primary product, ContraPest, is a liquid bait that re... |
| SNGX | Soligenix, Inc. | Soligenix is a biopharmaceutical company whose development pipeline relies on animal testing to satisfy regulatory requirements for product approval. Its lead biodefense vaccine candidates, including ... |
| SNN | Smith & Nephew SNATS, Inc. | Smith & Nephew SNATS, Inc., a subsidiary of Smith & Nephew PLC, is a global medical technology company that develops and markets surgical devices, including orthopedic implants, sports medicine repair... |
| SNSE | SENSEI BIOTHERAPEUTICS INC | Sensei Biotherapeutics is a clinical-stage biotechnology company developing cancer immunotherapies. The company's research and development pipeline is preclinical and clinical-stage, a process that ty... |
| SNTI | SENTI BIOSCIENCES INC | Senti Biosciences is a biotechnology company whose core research and development activities involve animal testing. The company's SEC filings explicitly acknowledge that animal rights groups have targ... |
| SNWV | SANUWAVE HEALTH INC | SANUWAVE Health Inc. develops and commercializes medical devices using extracorporeal shock wave therapy, primarily for wound care applications such as diabetic foot ulcers. The company’s core technol... |
| SNY | Sanofi | Sanofi conducts animal testing as a core component of its pharmaceutical research and development. The company states that the use of animals in research is justified for human health benefits, and it... |
| SOPH | SOPHIA GENETICS SA | SOPHiA GENETICS SA is a healthcare technology company that develops genomic analysis platforms. The company’s research and development activities involve animal testing as part of its product developm... |
| SPRB | SPRUCE BIOSCIENCES INC | Spruce Biosciences Inc. is a late-stage biopharmaceutical company developing novel therapies for endocrine disorders. The company’s drug development pipeline relies on animal testing as a standard com... |
| SPRO | Spero Therapeutics, Inc. | Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company whose core business of developing novel antibacterial treatments necessitates animal testing as part of the drug development proc... |
| SPRY | ARS PHARMACEUTICALS INC | ARS Pharmaceuticals develops neffy, an epinephrine nasal spray for severe allergic reactions. Pharmaceutical development and FDA approval of neffy required preclinical animal testing for pharmacokinet... |
| SRDX | Surmodics, Inc. | Surmodics, Inc. develops, manufactures, and markets medical device coatings and in vitro diagnostic components. The company's product development and testing processes involve animal testing. Surmodic... |
| SRPT | Sarepta Therapeutics, Inc. | Sarepta Therapeutics develops and commercializes precision genetic medicines for rare diseases, a process that requires animal testing for regulatory compliance and product development. The company’s ... |
| SRRK | Scholar Rock Holding Corporation | Scholar Rock Holding Corporation is a late-stage biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s lead investigational candidate, apitegromab, and othe... |
| SRTS | Sensus Healthcare, Inc. | Sensus Healthcare, Inc. manufactures superficial radiation therapy (SRT) devices for treating skin cancers and keloids. The company’s product development and regulatory compliance activities involve a... |
| SRZN | SURROZEN INC | Surrozen Inc. is a biotechnology company whose core research and development activities rely on animal testing. The company’s primary therapeutic candidates, such as SZN-043 for severe liver disease, ... |
| SSII | SS INNOVATIONS INTERNATIONAL INC | SS Innovations International, Inc. manufactures and markets surgical robotic systems, including its flagship SSi Mantra platform, designed for use in cardiac, thoracic, and urological procedures. The ... |
| STAA | Staar Surgical | As a manufacturer of Class III medical devices, STAAR Surgical is required by the FDA and international regulators (EMA, NMPA) to conduct animal studies to prove biocompatibility and safety. SEC filin... |
| STIM | Neuronetics, Inc. | Neuronetics, Inc. is a medical technology company that develops and markets transcranial magnetic stimulation (TMS) devices for the treatment of major depressive disorder. The company's core product, ... |
| STOK | Stoke Therapeutics Inc | Stoke Therapeutics develops antisense oligonucleotide therapies to upregulate protein expression in genetic diseases including Dravet syndrome. Its drug pipeline requires preclinical animal testing pe... |
| STRO | Sutro Biopharma, Inc. | Sutro Biopharma, Inc. is a clinical-stage oncology company developing antibody-drug conjugates and other protein-based therapeutics. The development of such biologic drugs, particularly for regulatory... |
| STTK | SHATTUCK LABS INC | Shattuck Labs is a clinical-stage biotechnology company whose drug development pipeline requires animal testing. The company’s SEC filings explicitly state that its preclinical studies involve animal ... |
| STXS | STEREOTAXIS INC | Stereotaxis Inc. develops and manufactures robotic magnetic navigation systems designed for minimally invasive cardiac procedures. The core function of its technology, as documented in peer-reviewed l... |
| SUPN | Supernus Pharmaceuticals, Inc. | Supernus Pharmaceuticals, Inc. is a pharmaceutical company that develops and markets treatments for central nervous system disorders. The company is flagged by Cruelty Free Investors for animal exploi... |
| SVRA | Savara, Inc. | Savara Inc. is a clinical-stage pharmaceutical company developing novel therapies for serious rare respiratory diseases. Its drug development pipeline, as documented in its SEC filings, relies on prec... |
| SWTX | SpringWorks Therapeutics Inc | SpringWorks Therapeutics is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing as a required component of the preclinical research and regulatory appro... |
| SXTC | China SXT Pharmaceuticals, Inc. | China SXT Pharmaceuticals manufactures and distributes traditional Chinese medicine and pharmaceutical products. Its drug development activities require preclinical animal testing under regulatory req... |
| SYBX | Synlogic, Inc. | Synlogic, Inc. is a clinical-stage biotechnology company developing synthetic biotic medicines, which are engineered strains of bacteria designed to treat diseases by performing metabolic functions in... |
| SYK | Stryker Corporation | Stryker Corporation uses animal testing as part of its medical device development and regulatory compliance process. The company's product research includes studies on the effects of its surgical equi... |
| SYRE | SPYRE THERAPEUTICS INC | Spyre Therapeutics is a clinical-stage biotechnology company developing SPY001 (alpha-4-beta-7 x TL1A bispecific antibody) and other biologics for inflammatory bowel disease. Clinical development prog... |
| SYRS | Syros Pharmaceuticals, Inc. | Syros Pharmaceuticals is a clinical-stage biopharmaceutical company that develops small molecule medicines for cancer and other diseases. As part of its drug development pipeline, the company conducts... |
| TAK | Takeda Pharmaceutical Company Limited | Takeda Pharmaceutical Company Limited conducts animal testing as a core component of its pharmaceutical research and development. The company’s Shonan Research Center has been a documented site of ani... |
| TARS | TARSUS PHARMACEUTICALS INC | Tarsus Pharmaceuticals develops ophthalmic therapeutics including XDEMVY (lotilaner) for Demodex blepharitis and pipeline candidates TP-03 and TP-05. Pharmaceutical development and FDA approval requir... |
| TBPH | Theravance Biopharma, Inc. | Theravance Biopharma, Inc. is a clinical-stage biopharmaceutical company whose core business model involves the discovery, development, and commercialization of novel medicines. This research and deve... |
| TCON | TRACON Pharmaceuticals, Inc. | TRACON Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company whose core business model involves the development of novel cancer therapeutics. This process inherently requires extensive a... |
| TCRT | ALAUNOS THERAPEUTICS INC | Alaunos Therapeutics is a clinical-stage oncology company developing TCR-T cell therapies. Its preclinical drug development pipeline requires animal testing for regulatory compliance and safety assess... |
| TCRX | TSCAN THERAPEUTICS INC | TScan Therapeutics Inc. is a clinical-stage biopharmaceutical company whose core research and development activities rely on animal testing. The company develops T cell receptor-engineered T cell ther... |
| TECH | Bio-Techne Corp | Bio-Techne Corp is a global life sciences company that develops and sells tools and reagents for biomedical research and clinical diagnostics. A core part of its business involves the production of an... |
| TECX | TECTONIC THERAPEUTIC INC | Tectonic Therapeutic develops biologic therapies targeting GPCR pathways for immunological and metabolic diseases. Its drug pipeline requires preclinical animal testing under FDA regulatory requiremen... |
| TEM | TEMPUS AI INC | Tempus AI develops artificial intelligence tools for medical research, including models trained on data derived from animal testing. The company’s SEC filings disclose that animal rights groups have t... |
| TENX | Tenax Therapeutics, Inc. | Tenax Therapeutics, Inc. is a pharmaceutical company whose drug development pipeline relies on animal testing. The company’s lead investigational drug, levosimendan, has been studied in animal models ... |
| TERN | TERNS PHARMACEUTICALS INC | Terns Pharmaceuticals is a clinical-stage biopharmaceutical company whose core business model requires animal testing. The company develops small-molecule drug candidates for conditions like metabolic... |
| TFX | Teleflex Incorporated | Teleflex Incorporated designs, manufactures, and sells single-use medical devices, including surgical instruments and catheters, that are used in procedures performed on animals. The company's product... |
| TGTX | TG Therapeutics, Inc. | TG Therapeutics is a biotechnology company that develops and commercializes treatments for B-cell malignancies and autoimmune diseases. The company’s drug development pipeline relies on preclinical an... |
| TIL | INSTIL BIO INC | Instil Bio Inc. is a clinical-stage biopharmaceutical company developing tumor-infiltrating lymphocyte (TIL) therapies for cancer. Its core research and development process necessitates animal testing... |
| TLPH | TALPHERA INC | Talphera, Inc. is a specialty pharmaceutical company that develops and commercializes therapies for use in medically supervised settings. The company’s product development pipeline, like that of most ... |
| TLSA | Tiziana Life Sciences plc | Tiziana Life Sciences plc is a biotechnology company whose drug development pipeline relies on animal testing. The company’s public filings document the completion of animal toxicology studies in spec... |
| TLSI | TRISALUS LIFE SCIENCES INC | TriSalus Life Sciences develops and commercializes medical devices and drug delivery systems for oncology treatments. The company’s business model inherently relies on animal testing to meet regulator... |
| TLX | TELIX PHARMACEUTICALS LTD | Telix Pharmaceuticals Ltd develops and commercializes radiopharmaceutical products for oncology and rare diseases. Its core business model involves preclinical and clinical research that requires anim... |
| TMDX | TRANSMEDICS GROUP INC | TransMedics develops the Organ Care System for transplant organ preservation. The technology was developed and validated using porcine (pig) heart, lung, and kidney models. Its 10-K explicitly acknowl... |
| TNGX | Tango Therapeutics Inc | Tango Therapeutics develops targeted cancer therapies using synthetic lethality. Its 10-K filings cite animal studies as foundational to preclinical development, and Cruelty Free Investors lists the c... |
| TNXP | Tonix Pharmaceuticals Holding Corp. | Tonix Pharmaceuticals Holding Corp. is a biopharmaceutical company whose research and development pipeline relies on animal testing. The company’s public disclosures and peer-reviewed publications con... |
| TNYA | Tenaya Therapeutics Inc | Tenaya Therapeutics is a clinical-stage biotechnology company whose core business model involves discovering and developing gene therapies for heart disease. The company’s published research and devel... |
| TPST | TEMPEST THERAPEUTICS INC | Tempest Therapeutics is a clinical-stage biotechnology company whose drug development pipeline relies on preclinical animal testing. The company’s public filings acknowledge the use of animal models a... |
| TRAW | TRAWS PHARMA INC | Traws Pharma Inc. is a clinical-stage biopharmaceutical company whose core business model involves developing new drug candidates. This process inherently requires animal testing for preclinical resea... |
| TRDA | ENTRADA THERAPEUTICS INC | Entrada Therapeutics is a clinical-stage biopharmaceutical company whose core business model involves the development of novel therapeutics through preclinical and clinical research. This research and... |
| TRIB | Trinity Biotech plc | Trinity Biotech plc develops, manufactures, and markets diagnostic test kits and instruments for clinical laboratories, including tests for infectious diseases, autoimmune disorders, and hemoglobin an... |
| TRML | TOURMALINE BIO INC | Tourmaline Bio is a clinical-stage biotechnology company developing TOUR006, an anti-IL-6 antibody for thyroid eye disease and other inflammatory conditions. Clinical drug development requires FDA-man... |
| TRVI | TREVI THERAPEUTICS INC | Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company whose primary drug candidate, oral nalbuphine ER, has been tested in animal models as part of its preclinical development. The co... |
| TRVN | Trevena, Inc. | Trevena, Inc. is a biopharmaceutical company whose core business is the development of novel central nervous system (CNS) drugs. The company’s drug development pipeline, which includes candidates for ... |
| TSHA | TAYSHA GENE THERAPIES INC | Taysha Gene Therapies is a clinical-stage biotechnology company focused on developing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system. As ... |
| TTNP | Titan Pharmaceuticals, Inc. | Titan Pharmaceuticals, Inc. is a biotechnology company whose core business model relies on animal testing for drug development and regulatory approval. The company's pipeline and published research ex... |
| TTOO | T2 Biosystems, Inc. | T2 Biosystems, Inc. is flagged for animal exploitation by Cruelty Free Investors. The company develops and markets in vitro diagnostic products, including the T2Bacteria and T2Candida panels, which ar... |
| TVGN | TEVOGEN BIO HOLDINGS INC | Tevogen Bio Holdings Inc. is a clinical-stage biotechnology company developing precision T cell therapeutics for oncology, neurology, and virology. A core component of its research and development pip... |
| TVRD | TVARDI THERAPEUTICS INC | Tvardi Therapeutics Inc. is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s foundational patents, such as US7517874B2, explicitly ref... |
| TVTX | Travere Therapeutics Inc | Travere Therapeutics is a biopharmaceutical company whose drug development pipeline requires animal testing as a core component of its preclinical research. The company’s public filings, including its... |
| TWST | Twist Bioscience Corporation | Twist Bioscience Corporation is a synthetic biology company that manufactures synthetic DNA, including for applications in antibody discovery and therapeutic development. According to Cruelty Free Inv... |
| TXG | 10X GENOMICS INC | 10x Genomics Inc. manufactures and sells single-cell analysis systems and consumables used in biomedical research. A core application of these products is preclinical animal testing, where researchers... |
| TXMD | TherapeuticsMD, Inc. | TherapeuticsMD, Inc. is a pharmaceutical company that develops and markets prescription hormone therapy drugs, including its FDA-approved products Bijuva, Imvexxy, and Annovera. The company's drug dev... |
| TYRA | TYRA BIOSCIENCES INC | Tyra Biosciences is a clinical-stage biotechnology company developing TYRA-300, a selective FGFR3 inhibitor for oncology. Preclinical research and clinical development require FDA-mandated animal stud... |
| ULTA | Ulta Beauty, Inc. | Ulta Beauty is a major retailer that stocks and profits from brands that conduct animal testing for cosmetics and personal care products. The company has not adopted a cruelty-free purchasing policy a... |
| UPB | UPSTREAM BIO INC | Upstream Bio Inc. is a clinical-stage biotechnology company whose business model is predicated on animal testing. The company’s drug development pipeline requires extensive preclinical testing on anim... |
| URGN | UroGen Pharma Ltd. | UroGen develops sustained-release urological therapies including mitomycin gel for bladder and upper tract cancers. Its drug-device combination products require preclinical animal testing per FDA regu... |
| USNA | USANA HEALTH SCIENCES INC | USANA Health Sciences, Inc. manufactures and sells nutritional supplements, skincare, and personal care products. The company's product development and safety testing historically relied on animal tes... |
| UTMD | Utah Medical Products, Inc. | Utah Medical Products, Inc. manufactures medical devices, including blood filters and catheters, that are explicitly designed and marketed for use in animal testing procedures. The company’s Hemo Nate... |
| VALN | Valneva SE | Valneva SE is a clinical-stage biotechnology company focused on developing and commercializing vaccines. Its vaccine candidates, including those for Zika (VLA1601) and Lyme disease (VLA15), require ex... |
| VANI | VIVANI MEDICAL INC | Vivani Medical, Inc. is a biotechnology company developing implantable drug delivery systems. Its lead product candidate, NPM-115, is a long-acting exenatide implant for chronic weight management. The... |
| VCEL | Vericel Corporation | Vericel Corporation develops and commercializes advanced cell therapies and specialty biologics for sports medicine and severe burn care. The company’s product development and regulatory approval proc... |
| VCYT | Veracyte, Inc. | Veracyte, Inc. is a molecular diagnostics company that develops genomic tests for cancer diagnosis. The company's product development pipeline includes preclinical animal testing as a standard compone... |
| VENU | VENU HOLDING CORP | Venu Holding Corp. is a publicly traded company flagged by Cruelty Free Investors for commercial exploitation of animals. The specific business activities or revenue streams that trigger this exclusio... |
| VERA | VERA THERAPEUTICS INC | Vera Therapeutics Inc. is a clinical-stage biotechnology company whose core business model is the discovery and development of novel pharmaceutical treatments. The development of such therapeutics, pa... |
| VERU | Veru Inc. | Veru develops oncology and urology therapeutics targeting androgen receptor and tubulin pathways. Its drug pipeline requires preclinical animal testing under FDA regulatory requirements. |
| VIR | Vir Biotechnology Inc | Vir Biotechnology develops immunology-based therapies for infectious diseases including COVID-19 antibody treatments and hepatitis B candidates. Its antiviral pipeline requires preclinical animal test... |
| VKTX | Viking Therapeutics, Inc. | Viking Therapeutics develops metabolic and endocrine therapies. Its lead candidate VK2735 is a dual GLP-1/GIP receptor agonist for obesity available in both subcutaneous and oral formulations. Phase 2... |
| VNDA | Vanda Pharmaceuticals, Inc. | Vanda develops therapeutics for central nervous system disorders including tradipitant for motion sickness and Hetlioz for circadian rhythm disorders. Its drug pipeline requires preclinical animal tes... |
| VOR | VOR BIOPHARMA INC | Vor Biopharma develops engineered hematopoietic stem cell therapies for blood cancers. Cell therapy development requires preclinical animal models for safety and engraftment studies. Excluded under an... |
| VRDN | VIRIDIAN THERAPEUTICS INC | Viridian Therapeutics is developing VRDN-003 and other antibody-based therapeutics for thyroid eye disease. Clinical-stage drug development programs require FDA-mandated preclinical animal pharmacolog... |
| VREX | VAREX IMAGING CORP | Varex Imaging manufactures X-ray imaging components and systems for medical and veterinary applications. Its medical imaging device development requires preclinical animal testing to meet FDA safety s... |
| VRNA | Verona Pharma plc | Verona Pharma is a clinical-stage biopharmaceutical company developing ensifentrine for chronic obstructive pulmonary disease (COPD). The company conducts preclinical animal testing as part of its res... |
| VRTX | Vertex Pharmaceuticals Incorporated | Vertex Pharmaceuticals develops transformative medicines for cystic fibrosis, pain, sickle cell disease, and kidney disease. Animal testing is integral to its drug development pipeline as required by ... |
| VSTM | Verastem, Inc. | Verastem Oncology develops targeted therapies for RAS/MAPK pathway-driven cancers. Its combination of avutometinib (a RAF/MEK inhibitor) and defactinib (a FAK inhibitor), branded as AVMAPKI/FAKZYNJA, ... |
| VTVT | vTv Therapeutics Inc. | vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company whose core business model relies on animal testing for drug development. The company’s pipeline of oral small molecule drug candidat... |
| VTYX | VENTYX BIOSCIENCES INC | Ventyx Biosciences is a clinical-stage biopharmaceutical company whose drug development pipeline relies on animal testing. The company’s own regulatory filings state that the results of animal studies... |
| VXRT | Vaxart, Inc. | Vaxart, Inc. is a clinical-stage biotechnology company that develops oral vaccine tablets. Its core research and development process involves preclinical animal testing to assess vaccine candidates fo... |
| VYGR | Voyager Therapeutics, Inc. | Voyager Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing gene therapies for neurological diseases. As a standard part of its drug development process, the company con... |
| VYNE | VYNE THERAPEUTICS INC | VYNE Therapeutics develops drugs for immuno-inflammatory conditions. A clinical hold was placed on its lead program after a safety signal emerged in dog studies, confirming active animal testing. Crue... |
| WBA | Walgreens Boots Alliance, Inc. | Walgreens Boots Alliance, through its Boots UK retail brand, has been flagged by ethical consumer platforms for receiving a bottom score on animal welfare. The company’s supply chain has been linked t... |
| WHWK | WHITEHAWK THERAPEUTICS INC | Whitehawk Therapeutics is a clinical-stage oncology therapeutics company. The company’s pipeline includes preclinical and clinical programs that require animal testing as a standard, mandatory compone... |
| WINT | Windtree Therapeutics, Inc. | Windtree Therapeutics, Inc. is a clinical-stage biotechnology company whose core business model involves the development of novel pharmaceuticals. This process inherently requires extensive animal tes... |
| WVE | WAVE Life Sciences Ltd. | Wave Life Sciences Ltd. is a clinical-stage genetic medicines company whose drug development pipeline relies on animal testing to advance therapeutic candidates. The company's public research disclosu... |
| XAIR | BEYOND AIR INC | Beyond Air develops nitric oxide-based therapies delivered via its LungFit platform for respiratory conditions. Its drug-device combination products require preclinical animal testing per FDA regulati... |
| XBIO | Xenetic Biosciences, Inc. | Xenetic Biosciences is a clinical-stage biopharmaceutical company focused on developing immuno-oncology technologies. Its core business model involves advancing biologic drug candidates through precli... |
| XBIT | XBiotech Inc. | XBiotech Inc. is a pre-market biopharmaceutical company engaged in discovering and developing monoclonal antibody therapeutics for inflammatory diseases and cancer. The company’s Form S-1 registration... |
| XENE | Xenon Pharmaceuticals Inc. | Xenon Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company whose business model is predicated on animal testing for regulatory compliance and product development. The company’s pipeline ... |
| XERS | Xeris Pharmaceuticals, Inc. | Xeris develops ready-to-use injectable and infusible drug formulations including glucagon products for severe hypoglycemia. Its drug delivery pipeline requires preclinical animal testing per FDA regul... |
| XFOR | X4 PHARMACEUTICALS INC | X4 Pharmaceuticals, Inc. conducts animal testing as a core component of its drug development and regulatory compliance process. The company’s SEC filings consistently disclose adherence to Good Labora... |
| XGN | EXAGEN INC | Exagen Inc. is a biotechnology company whose product development and testing processes rely on animal experimentation. The company is listed by Cruelty Free Investors as a company that exploits animal... |
| XLO | XILIO THERAPEUTICS INC | Xilio Therapeutics is a clinical-stage biotechnology company developing tumor-selective immunotherapies for cancer. The company’s research and development process involves preclinical animal testing, ... |
| XNCR | Xencor, Inc. | Xencor, Inc. develops bispecific and engineered antibody therapies for cancer and autoimmune diseases, a process that requires animal testing to meet regulatory standards for safety and efficacy. The ... |
| XOMA | XOMA Corporation | XOMA Corporation is a biotechnology company whose business model is built on developing and licensing antibody-based therapeutics. The drug discovery and development process for such products inherent... |
| XRAY | DENTSPLY SIRONA Inc. | DENTSPLY SIRONA Inc. is flagged for animal exploitation based on its inclusion in the Cruelty Free Investing list of "Companies That Exploit Animals," which specifically categorizes the company under ... |
| XTLB | XTL Biopharmaceuticals Ltd. | XTL Biopharmaceuticals Ltd. (XTLbio) is a biopharmaceutical company whose core business model involves the development of novel therapeutics for hepatitis B and C. A foundational aspect of this develo... |
| XTNT | Xtant Medical Holdings, Inc. | Xtant Medical Holdings, Inc. develops, manufactures, and markets regenerative medical products, including bone graft substitutes and spinal fixation devices. The company’s product development pipeline... |
| YDES | YD BIOPHARMA LTD | YD Biopharma (formerly YD Bio Limited) develops an integrated oncology ecosystem spanning diagnostics and therapeutics. Through its subsidiary EG BioMed, the company commercializes proprietary DNA met... |
| YI | 111, Inc. | 111, Inc. operates a digital healthcare platform in China that includes pharmaceutical distribution. Its affiliated entities develop drug candidates requiring preclinical animal testing under FDA and ... |
| YMAB | Y-mAbs Therapeutics, Inc. | Y-mAbs Therapeutics, Inc. is a clinical-stage biopharmaceutical company whose business model is predicated on animal testing. The company's core pipeline of antibody-based cancer therapeutics requires... |
| YSG | YATSEN HOLDING LTD | Yatsen is a Chinese beauty and skincare company whose brands include Perfect Diary and Eve Lom. Its cosmetics products are subject to mandatory animal testing under Chinese regulatory requirements. |
| ZBH | Zimmer Biomet Holdings, Inc. | Zimmer Biomet Holdings, Inc. is a global medical device company specializing in musculoskeletal healthcare, including orthopedic implants, surgical robotics, and sports medicine products. The company'... |
| ZBIO | ZENAS BIOPHARMA INC | Zenas BioPharma is a clinical-stage biopharmaceutical company whose core business involves developing therapeutic candidates that require animal testing for regulatory approval and research. The compa... |
| ZIMV | ZIMVIE INC | ZimVie Inc. manufactures and markets medical devices, including dental implants and spinal surgery hardware, that incorporate materials derived from animals. Its product portfolio includes bone graft ... |
| ZLAB | Zai Lab Limited | Zai Lab Limited is a biopharmaceutical company that develops and commercializes oncology, autoimmune, and infectious disease therapies. As a drug developer, its research pipeline inherently involves a... |
| ZNTL | Zentalis Pharmaceuticals Inc | Zentalis Pharmaceuticals conducts preclinical animal studies as a standard part of its drug development process. The company’s SEC filings routinely cite the “completion of preclinical laboratory test... |
| ZTS | Zoetis Inc. | Zoetis Inc. develops, manufactures, and sells animal health medicines, vaccines, and diagnostics, a business model that inherently requires animal testing for product development and regulatory compli... |
| ZVRA | ZEVRA THERAPEUTICS INC | Zevra Therapeutics is a commercial-stage rare disease pharmaceutical company whose drug development pipeline relies on animal testing as a standard regulatory requirement. The company’s research activ... |
| ZYME | Zymeworks Inc. | Zymeworks Inc. is a clinical-stage biotechnology company whose core business of discovering and developing novel biotherapeutics requires animal testing as a standard component of its preclinical rese... |
The Naughty List
A digest of changes to our exclusion list — new additions, removals, and the evidence behind them. We review the list continuously as new evidence surfaces.
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